Common Pathogenic Pathways and Therapeutics for SMA and ALS motoneuron diseases

SMA 和 ALS 运动神经元疾病的常见致病途径和治疗方法

• 批准号: 312153
• 负责人: Kothary Rashmi K
• 金额: $ 28.42万
• 依托单位: Ottawa Hospital Research Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-05-01 至 2017-05-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=312153&lang=en
• 关键词: Adeno-Associated Virus; Als; Fas; Motoneuron; Mouse Model; Sma Patients; Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is an incurable paralytic neuromuscular disorder that mainly affects children at an incidence of 1 in 6000 to 10000 births. SMA is characterized by the selective degeneration of spinal motoneurons. About 95% of SMA cases are

脊髓性肌萎缩症是一种无法治愈的神经肌肉疾病，主要影响儿童，发病率为每6000至10000名新生儿中就有一例。SMA的特点是脊髓运动神经元选择性变性。大约95%的SMA病例是