CellMechBio: the influence of cellular mechanobiology on organ development

CellMechBio：细胞力学生物学对器官发育的影响

• 批准号: FT230100352
• 负责人: A/Prof James Osborne
• 金额: $ 67.37万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100352
• 关键词: CellMechBio; influence; cellular; mechanobiology; organ

Through a set of collaborative interdisciplinary application projects, with open scientific questions, this project aims to develop cutting edge mechanobiological mathematical models of organ development and function. The expected outcomes of this project are a step-change in the fidelity of multicellular models of three-dimensional tissues and the scientific investigations into the mechanobiological processes regulating organ development, currently not possible, that these models support. In addition to significant benefits from advances in fundamental mathematical and biological knowledge, this project plans to develop a mechanobiological modelling framework made available to the wider scientific community by an open source release.

通过一系列合作的跨学科应用项目，开放的科学问题，该项目旨在开发器官发育和功能的尖端机械生物学数学模型。 该项目的预期成果是三维组织的多细胞模型的保真度的一个步骤的变化和调节器官发育的机械生物学过程的科学调查，目前还不可能，这些模型支持。 除了从基础数学和生物学知识的进步中获得重大利益外，该项目还计划开发一个机械生物学建模框架，通过开源版本提供给更广泛的科学界。