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Neurodevelopment of exploration and alcohol problems in adolescence

青春期探索和酒精问题的神经发育

基本信息

批准号：
10628964
负责人：
Jeremy P Hogeveen
金额：
$ 59.39万
依托单位：
UNIVERSITY OF NEW MEXICO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-05 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628964
关键词：
Acceleration Address Adolescence Adolescent Adolescent and Young Adult Adult Affective Alcohol abuse Alcohol consumption Alcohols Amygdaloid structure Automobile Driving Behavior Behavioral Mechanisms Biological Assay Brain Cellular Phone Chronic Clinical Cognitive Computer Models Corpus striatum structure Cross-Sectional Studies Curiosities Data Decision Making Decision Trees Development Dimensions Dissociation Environment Exploratory Behavior Food Friends Functional Magnetic Resonance Imaging Future Goals Growth Health Individual Intervention Laboratories Learning Life Link Lobule Longitudinal Studies Measurement Measures Methods Modeling Motivation Neurons Neurosciences Parents Participant Personality Persons Phenotype Positioning Attribute Prefrontal Cortex Punishment Randomized Research Research Personnel Rewards Risk Science Sensory Severities Shapes Stimulus Testing Visit Work Youth addiction adolescent alcohol abuse age related alcohol monitoring alcohol research alcohol risk alcohol use disorder chronic alcohol ingestion design diaries disorder risk drinking early drinking experience experimental study improved in vivo innovation neural neural circuit neurodevelopment neuroimaging neuromechanism novel peer predictive test preference preventable death preventive intervention programs random forest recruit reduced alcohol use resilience response skills social social influence societal costs tool trait underage drinking young adult

项目摘要

PROJECT SUMMARY Exploring novel and unfamiliar foods, friend groups, and activities during adolescence critically shapes our preferences and personalities in adulthood. Conversely, for adolescents who engage in underage drinking, such novelty-seeking can be maladaptive and lead to the development of chronic alcohol use problems. Cross- sectional studies suggest that individuals become more strategic in their use of goal-directed exploration to optimize choice during the transition from adolescence to young adulthood. The core hypothesis of the proposed study is that the maturation of directed exploration is blunted or lagged in adolescents who experiment with alcohol and go on to develop increased alcohol use problems. Specifically, we will conduct an accelerated longitudinal fMRI study of N=135 participants (recruited at 13-21 years), merging clinical assays of alcohol use severity, computational modeling of novelty-driven exploration across multiple tasks, model-based decomposition of fMRI data at three longitudinal timepoints, and smartphone-based daily diary assessments to probe alcohol- and novelty-related decision making in vivo outside of the laboratory. In Aim 1 we will test the hypothesis that the normative maturation of novelty-driven exploration—i.e., expansion of strategic, goal- directed exploration to optimize choice—will be negatively modulated by increased alcohol use severity. Further, we will use longitudinal model-based fMRI to determine whether this expansion of directed exploration is driven by age-related increases in neural encoding of the latent value of exploring new options in frontoparietal (i.e., frontopolar cortex, dorsolateral prefrontal cortex, and intraparietal lobule) and motivational (i.e., striatum, amygdala, and orbitofrontal cortex) neural circuits. In Aim 2 we will contrast novelty-driven exploration to maximize gains versus minimize losses, hypothesizing that the presence of potential punishments should decrease exploratory behavior as individuals are motivated to avoid potential losses. Differentiation between reward- and punishment-evoked neural responses is blunted in adolescents with alcohol use problems, therefore we hypothesize that differential gating of novelty exploration across gain versus loss contexts will be diminished in adolescents with higher alcohol use severity. Lastly, in Aim 3 we will use daily diary prompts delivered via smartphone to determine the ecological relevance of our laboratory- based decision making assays for predicting real-world alcohol- and novelty-directed behaviors. This triangulation of computational phenotyping, neuroimaging, and ecologically-situated assessments has not been performed in existing studies, and could identify a new novelty-driven exploration dimension to be considered in future iterations of the Addictions Neuroclinical Assessment framework. In line with the Katz Early Stage Investigator mechanism—this computational developmental science approach will represent an innovative advance that will launch the PI in a new research direction: leveraging his skills and expertise in adolescent neuroimaging to focus on the development of decision making neurocircuitry and risk for alcohol use problems in adolescence.

项目总结