Conjugation and intracellular delivery of biomolecular cargo

生物分子货物的缀合和细胞内递送

• 批准号: 470366-2014
• 负责人: Keillor, Jeffrey
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=564108
• 关键词: Conjugation; intracellular; delivery; biomolecular; cargo

iProgen has developed a series of cell permeable peptides capable of delivering large cargo biomolecules, to which they are fused, into human cells. iProgen is interested in applying this technology to deliver a variety of biologically relevant cargo molecules. iProgen Biotech and Dr. Keillor will collaborate on the design, synthesis and evaluation of a modular linking technology for attaching different biologically relevant cargo molecules to the cell permeable peptides. The development of such technology will expand the range of cargo that iProgen's technology can deliver, as well as accelerate the process of screening for both suitable drug cargoes and enhanced delivery agents. The successful validation of this modular conjugation technology will also result in the development of promising new therapeutics technology that will benefit human health.

iProgen开发了一系列细胞可渗透肽，能够将与其融合的大货物生物分子递送到人细胞中。iProgen有兴趣应用这项技术来递送各种生物相关的货物分子。iProgen Biotech和Keillor博士将合作设计、合成和评估一种模块化连接技术，用于将不同的生物相关货物分子连接到细胞可渗透肽上。这种技术的开发将扩大iProgen技术可以提供的货物范围，并加快筛选合适的药物货物和增强的递送剂的过程。这种模块化缀合技术的成功验证也将导致有前途的新治疗技术的发展，这将有利于人类健康。