Investigating the effects of drug dependence and traumatic stress on CRF upregulation in the ventral tegmental area and cortical neurons

研究药物依赖性和创伤应激对腹侧被盖区和皮质神经元 CRF 上调的影响

• 批准号: 318812
• 负责人: Grieder Taryn E
• 金额: $ 9.71万
• 依托单位: Scripps Research Institute (La Jolla, CA)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-11-01 至 2017-07-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=318812&lang=en
• 关键词: Adeno-Associated Viral Knockdown; Brain Reward System; Corticotropin-Releasing Factor; Drug Dependence; Drug Withdrawal; Inescapable Shock; Post-Traumatic Stress; Prefrontal Cortex; Self-Administration; Vulnerability

Drug abuse is a major public health concern in North America. A greater understanding of the brain mechanisms that underlie drug addiction and relapse will lead to the development of new treatments, thus improving the treatment of drug addiction and conse

药物滥用是北美一个主要的公共卫生问题。对药物成瘾和复吸的大脑机制有更深入的了解，将有助于开发新的治疗方法，从而改善药物成瘾的治疗，