A novel therapeutic application of closed-loop neuromodulation of the brain reward system in nicotine use disorder

大脑奖励系统闭环神经调节在尼古丁使用障碍中的新治疗应用

基本信息

  • 批准号:
    10583658
  • 负责人:
  • 金额:
    $ 22.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-05-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Decades of animal models have taught us that addiction is, indeed, a disorder of dysregulated neural circuits. However, there are currently no circuit-based biomarkers or treatments for human patients. Transcranial magnetic stimulation (TMS) has the potential to radically transform how substance use disorders (SUDs) are treated. Presently, multiple sessions of 10-Hz repetitive TMS (rTMS) passively applied over the left dorsal lateral prefrontal cortex (DLPFC) for 20 to 30 min (2000–3000 pulses) has recently been adopted for the treatment of nicotine use disorder (NUD), particularly reducing craving and cigarette consumption. It has been suggested that the observed modulation of the mesocorticolimbic reward circuitry by 10-Hz prefrontal rTMS might mediate the therapeutic effects of TMS in NUD and other substance-related disorders. However, in clinical practices, a half- hour TMS therapy 5 days a week could take weeks to be fully effective, and its therapeutic efficacy remains limited and varies greatly across individuals. Thus, the primary goal of this proposal is to develop a faster and more concentrated TMS protocol that may reduce the treatment time length and increase its clinical efficiency by more precisely identifying and actively targeting the reward circuitry and proximal functions. Building on recent advances in combining TMS with EEG, which allow TMS protocols to be directly controlled by the EEG signal (closed-loop modulation), we aim to test a novel close-loop TMS intervention capable of real-time tracking and modulation of distinct episodes of reward-related midcingulate cortex (MCC) activity in nicotine-dependent individuals. This approach potentially offers bidirectional treatments that are spatially, temporally, and cognitively precise. Our lab and others have identified oscillatory EEG signals in the theta band over frontal sites (frontal midline theta, FMT) that accompany dopaminergic reward prediction errors, and that are altered in NUD and other substance use disorders. Since the phase of oscillations in the EEG can reflect local processing, the timing of TMS pulses to precise periods during these rhythms should have direct neural, behavioral, and computational effects, and thereby improved clinical outcomes. Thus, we have developed a novel closed-loop system capable of tracking these theta oscillations in real-time and using that information to control delivery of TMS. This proposal seeks to test the neural, computational, behavioral efficacy of these protocols for modulating MCC reward function (Aim 1), and then test whether precisely triggering TMS synchronized with the peak or trough of FMT oscillations would temporarily reduce the subjective craving triggered by exposure to smoking cues in nicotine- dependent adult smokers (Aim 2). This project is innovative because it enables the possibility to instantaneously probe the MCC neural response pattern and to deliver TMS manipulations as they occur during reward-directed behavior. The proposed research is significant, because the scientific knowledge will provide best practices to choose stimulation parameters that will advance the treatment for particular neurocognitive processes involved in both NUD and other substance-related disorders.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Travis E. Baker其他文献

Theta Burst Stimulation of the Hyperdirect Pathway Boosts Inhibitory Control and Reduces Craving and Smoking in Nicotine-Dependent Adults
超直接通路的θ爆发刺激可增强抑制控制并减少尼古丁依赖成人的渴望和吸烟
Accelerated Deep Transcranial Magnetic Stimulation for Stimulant Use Disorder
用于兴奋剂使用障碍的加速深度经颅磁刺激
  • DOI:
    10.1016/j.brs.2024.12.1012
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    8.400
  • 作者:
    Emma Bousseau;Maxime Richard;Véronique Desbeaumes Jodoin;Daniel Blumberger;Travis E. Baker;Elie Bou Assi;Simon Dubreuq;Paul Robert Juster;Didier Jutras Aswad;Paul Lespérance;Jean-Philippe Miron
  • 通讯作者:
    Jean-Philippe Miron
Recording neural reward signals in the real-world using mobile-EEG and augmented reality
使用移动脑电图和增强现实记录现实世界中的神经奖励信号
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jaleesa Stringfellow;Omer Liran;Mei;Travis E. Baker
  • 通讯作者:
    Travis E. Baker
Protocol state fuzzing of an OpenVPN
OpenVPN 的协议状态模糊测试
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jaleesa Stringfellow;Omer Liran;Mei;Travis E. Baker
  • 通讯作者:
    Travis E. Baker

Travis E. Baker的其他文献

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{{ truncateString('Travis E. Baker', 18)}}的其他基金

Recovery of reward function in nicotine use disorder using a combination of robotics, electrophysiology, and TMS
结合机器人技术、电生理学和 TMS 恢复尼古丁使用障碍的奖励功能
  • 批准号:
    10707923
  • 财政年份:
    2022
  • 资助金额:
    $ 22.7万
  • 项目类别:
Recovery of reward function in nicotine use disorder using a combination of robotics, electrophysiology, and TMS
结合机器人技术、电生理学和 TMS 恢复尼古丁使用障碍的奖励功能
  • 批准号:
    10467430
  • 财政年份:
    2022
  • 资助金额:
    $ 22.7万
  • 项目类别:
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
儿童实体非中枢神经系统肿瘤患者化疗引起的神经认知缺陷的候选机制
  • 批准号:
    10445042
  • 财政年份:
    2021
  • 资助金额:
    $ 22.7万
  • 项目类别:
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
儿童实体非中枢神经系统肿瘤患者化疗引起的神经认知缺陷的候选机制
  • 批准号:
    10285050
  • 财政年份:
    2021
  • 资助金额:
    $ 22.7万
  • 项目类别:
Using combined EEG and non-invasive brain stimulation to examine and improve reward functioning in opioid use disorder
使用脑电图和非侵入性脑刺激相结合来检查和改善阿片类药物使用障碍的奖励功能
  • 批准号:
    10393943
  • 财政年份:
    2020
  • 资助金额:
    $ 22.7万
  • 项目类别:

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