A novel therapeutic application of closed-loop neuromodulation of the brain reward system in nicotine use disorder
大脑奖励系统闭环神经调节在尼古丁使用障碍中的新治疗应用
基本信息
- 批准号:10583658
- 负责人:
- 金额:$ 22.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdoptedAdultAffectiveAlgorithmsAnimal ModelAnteriorBehaviorBehavioralBiological MarkersBrainCigaretteClinicalCognitiveComputer ModelsConsumptionDataDecision MakingDiseaseDopamineDorsalEducational process of instructingElectroencephalographyElectrophysiology (science)Exposure toFeedbackGoalsHealthHealthcare SystemsHourHumanIndividualInterventionInvestigationKnowledgeLateralLeftLengthLinkMeasuresMediatingMethodsMonitorNeurocognitiveNeurocognitive DeficitNicotine DependenceNicotine Use DisorderOutcomePathway interactionsPatientsPatternPerformancePharmaceutical PreparationsPhasePhysiologic pulsePlayPrefrontal CortexProcessProtocols documentationResearchRestRewardsRoboticsRoleSignal TransductionSiteSmokerSubstance Use DisorderSubstance-Related DisordersSystemTestingTherapeutic EffectTimeTrainingTranscranial magnetic stimulationTreatment EfficacyWorkaddictionbrain basedcigarette cravingclinical practicecognitive abilitycravingdrug seeking behaviorefficacy testingimprovedinnovationneuralneural circuitneuroregulationnicotine cuenicotine treatmentnoninvasive brain stimulationnovelnovel therapeuticsoperationrepetitive transcranial magnetic stimulationresponsereward circuitrysignal processingsmoking cuesubstance use treatmentsuccesstreatment programvirtual
项目摘要
PROJECT SUMMARY/ABSTRACT
Decades of animal models have taught us that addiction is, indeed, a disorder of dysregulated neural circuits.
However, there are currently no circuit-based biomarkers or treatments for human patients. Transcranial
magnetic stimulation (TMS) has the potential to radically transform how substance use disorders (SUDs) are
treated. Presently, multiple sessions of 10-Hz repetitive TMS (rTMS) passively applied over the left dorsal lateral
prefrontal cortex (DLPFC) for 20 to 30 min (2000–3000 pulses) has recently been adopted for the treatment of
nicotine use disorder (NUD), particularly reducing craving and cigarette consumption. It has been suggested that
the observed modulation of the mesocorticolimbic reward circuitry by 10-Hz prefrontal rTMS might mediate the
therapeutic effects of TMS in NUD and other substance-related disorders. However, in clinical practices, a half-
hour TMS therapy 5 days a week could take weeks to be fully effective, and its therapeutic efficacy remains
limited and varies greatly across individuals. Thus, the primary goal of this proposal is to develop a faster and
more concentrated TMS protocol that may reduce the treatment time length and increase its clinical efficiency
by more precisely identifying and actively targeting the reward circuitry and proximal functions. Building on recent
advances in combining TMS with EEG, which allow TMS protocols to be directly controlled by the EEG signal
(closed-loop modulation), we aim to test a novel close-loop TMS intervention capable of real-time tracking and
modulation of distinct episodes of reward-related midcingulate cortex (MCC) activity in nicotine-dependent
individuals. This approach potentially offers bidirectional treatments that are spatially, temporally, and cognitively
precise. Our lab and others have identified oscillatory EEG signals in the theta band over frontal sites (frontal
midline theta, FMT) that accompany dopaminergic reward prediction errors, and that are altered in NUD and
other substance use disorders. Since the phase of oscillations in the EEG can reflect local processing, the timing
of TMS pulses to precise periods during these rhythms should have direct neural, behavioral, and computational
effects, and thereby improved clinical outcomes. Thus, we have developed a novel closed-loop system capable
of tracking these theta oscillations in real-time and using that information to control delivery of TMS. This proposal
seeks to test the neural, computational, behavioral efficacy of these protocols for modulating MCC reward
function (Aim 1), and then test whether precisely triggering TMS synchronized with the peak or trough of FMT
oscillations would temporarily reduce the subjective craving triggered by exposure to smoking cues in nicotine-
dependent adult smokers (Aim 2). This project is innovative because it enables the possibility to instantaneously
probe the MCC neural response pattern and to deliver TMS manipulations as they occur during reward-directed
behavior. The proposed research is significant, because the scientific knowledge will provide best practices to
choose stimulation parameters that will advance the treatment for particular neurocognitive processes involved
in both NUD and other substance-related disorders.
项目概要/摘要
数十年的动物模型告诉我们,成瘾确实是一种神经回路失调的疾病。
然而,目前还没有针对人类患者的基于回路的生物标志物或治疗方法。经颅
磁刺激 (TMS) 有可能从根本上改变物质使用障碍 (SUD) 的治疗方式
治疗。目前,多次 10 Hz 重复 TMS (rTMS) 被动地应用于左侧背外侧
前额皮质 (DLPFC) 20 至 30 分钟(2000-3000 次脉冲)最近已被用于治疗
尼古丁使用障碍 (NUD),特别是减少烟瘾和香烟消费。有人建议
观察到的 10 Hz 前额叶 rTMS 对中皮质边缘奖励电路的调节可能会介导
TMS 对 NUD 和其他物质相关疾病的治疗效果。但在临床实践中,半
每周 5 天每小时 TMS 治疗可能需要数周时间才能完全生效,而且其治疗效果仍然存在
有限且因人而异。因此,该提案的主要目标是开发一个更快、更
更集中的 TMS 方案可缩短治疗时间并提高临床效率
通过更精确地识别并积极瞄准奖励回路和近端功能。建立在最近的基础上
TMS 与 EEG 相结合的进展,使得 TMS 协议可以直接由 EEG 信号控制
(闭环调制),我们的目标是测试一种新颖的闭环 TMS 干预,能够实时跟踪和
尼古丁依赖性奖励相关中扣带皮层(MCC)活动的不同发作的调节
个人。这种方法有可能提供空间、时间和认知上的双向治疗
精确的。我们的实验室和其他人已经在额叶部位(额叶)的 theta 波段中识别出振荡脑电图信号
中线 theta,FMT)伴随着多巴胺能奖励预测错误,并且在 NUD 和
其他物质使用障碍。由于脑电图振荡的相位可以反映局部处理,因此时间
TMS 脉冲在这些节律期间的精确周期应该具有直接的神经、行为和计算能力
效果,从而改善临床结果。因此,我们开发了一种新颖的闭环系统,能够
实时跟踪这些 θ 振荡并使用该信息来控制 TMS 的传输。这个提议
旨在测试这些协议调节 MCC 奖励的神经、计算和行为功效
功能(目标1),然后测试是否精确触发TMS与FMT的波峰或波谷同步
振荡会暂时减少因接触尼古丁中的吸烟线索而引发的主观渴望
受抚养的成年吸烟者(目标 2)。该项目具有创新性,因为它可以立即
探测 MCC 神经反应模式并在奖励导向期间进行 TMS 操作
行为。拟议的研究意义重大,因为科学知识将为
选择刺激参数,以促进所涉及的特定神经认知过程的治疗
NUD 和其他物质相关疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Travis E. Baker其他文献
Theta Burst Stimulation of the Hyperdirect Pathway Boosts Inhibitory Control and Reduces Craving and Smoking in Nicotine-Dependent Adults
超直接通路的θ爆发刺激可增强抑制控制并减少尼古丁依赖成人的渴望和吸烟
- DOI:
10.1016/j.bpsc.2023.09.007 - 发表时间:
2023-11-01 - 期刊:
- 影响因子:4.800
- 作者:
Travis E. Baker;Daniel Robles - 通讯作者:
Daniel Robles
Accelerated Deep Transcranial Magnetic Stimulation for Stimulant Use Disorder
用于兴奋剂使用障碍的加速深度经颅磁刺激
- DOI:
10.1016/j.brs.2024.12.1012 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:8.400
- 作者:
Emma Bousseau;Maxime Richard;Véronique Desbeaumes Jodoin;Daniel Blumberger;Travis E. Baker;Elie Bou Assi;Simon Dubreuq;Paul Robert Juster;Didier Jutras Aswad;Paul Lespérance;Jean-Philippe Miron - 通讯作者:
Jean-Philippe Miron
Recording neural reward signals in the real-world using mobile-EEG and augmented reality
使用移动脑电图和增强现实记录现实世界中的神经奖励信号
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Jaleesa Stringfellow;Omer Liran;Mei;Travis E. Baker - 通讯作者:
Travis E. Baker
Protocol state fuzzing of an OpenVPN
OpenVPN 的协议状态模糊测试
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Jaleesa Stringfellow;Omer Liran;Mei;Travis E. Baker - 通讯作者:
Travis E. Baker
Travis E. Baker的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Travis E. Baker', 18)}}的其他基金
Recovery of reward function in nicotine use disorder using a combination of robotics, electrophysiology, and TMS
结合机器人技术、电生理学和 TMS 恢复尼古丁使用障碍的奖励功能
- 批准号:
10707923 - 财政年份:2022
- 资助金额:
$ 22.7万 - 项目类别:
Recovery of reward function in nicotine use disorder using a combination of robotics, electrophysiology, and TMS
结合机器人技术、电生理学和 TMS 恢复尼古丁使用障碍的奖励功能
- 批准号:
10467430 - 财政年份:2022
- 资助金额:
$ 22.7万 - 项目类别:
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
儿童实体非中枢神经系统肿瘤患者化疗引起的神经认知缺陷的候选机制
- 批准号:
10445042 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
Candidate mechanisms for chemotherapy-induced neurocognitive deficits in pediatric solid non-CNS tumor patients
儿童实体非中枢神经系统肿瘤患者化疗引起的神经认知缺陷的候选机制
- 批准号:
10285050 - 财政年份:2021
- 资助金额:
$ 22.7万 - 项目类别:
Using combined EEG and non-invasive brain stimulation to examine and improve reward functioning in opioid use disorder
使用脑电图和非侵入性脑刺激相结合来检查和改善阿片类药物使用障碍的奖励功能
- 批准号:
10393943 - 财政年份:2020
- 资助金额:
$ 22.7万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 22.7万 - 项目类别:
Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
- 批准号:
2230829 - 财政年份:2023
- 资助金额:
$ 22.7万 - 项目类别:
Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 22.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 22.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 22.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)