Neurobiological mechanisms of the interaction between pain and sleep

疼痛与睡眠相互作用的神经生物学机制

• 批准号: FT230100235
• 负责人: A/Prof Natalia Egorova-Brumley
• 金额: $ 68.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100235
• 关键词: Neurobiological; mechanisms; interaction; between; pain

The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimodal dataset generated by the project will be made publicly available to enhance research transparency and international collaboration. This should provide significant benefits, ultimately opening up ways to improve quality of life and wellbeing of the Australian population.

该项目旨在揭示睡眠和疼痛等基本生物现象之间相互作用的大脑机制。这个高度跨学科的项目希望通过结合新颖的基于实验室的机械睡眠和疼痛操纵以及自然主义的纵向观察，对睡眠不足如何改变大脑以增加健康成年人的疼痛敏感性提供重要的见解。该项目生成的丰富的多模式数据集将公开提供，以提高研究透明度和国际合作。这将带来巨大的好处，最终为改善澳大利亚人口的生活质量和福祉开辟道路。