Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors

项目摘要 这个K23指导的以患者为导向的研究职业发展奖的目标是为候选人 获得儿童期威胁暴露，社会动机（SM）和自杀想法风险方面的专业知识， 行为（STBs）。儿童期威胁暴露通过影响相关的大脑功能增加了STBs的风险 人际压力青春期充满了人际压力;然而，并非所有的青少年都有童年， 威胁暴露经历STB，表明其他因素加剧了风险。找出更多 与威胁相互作用以增加性病的因素对于确定新的自杀预防目标至关重要 机制等这个项目将确定是否SM代表一个额外的因素，缓和的联系 儿童期接触威胁和性传播疾病之间的联系该奖项的培训目标将包括以下方面的技能获取： (1)儿童期威胁暴露和SM的发展心理病理学模型，（2）神经生物学和 STBs风险的行为机制，以及（3）大脑的高级强化时间序列建模 连通性。培训将促进进行自我报告、大脑和行为特征研究的能力 青少年SM的措施（目的1），以检查是否适应不良的社会动机加强联系 威胁暴露与STB之间的关系（目标2）。最终探索性目标3将允许进行初步调查 青春期、生理性别和年龄如何进一步缓和威胁暴露与SM之间的相互作用， 机顶盒本研究将利用两个R 01项目在两个队列中测试目的;队列1（n = 220）包括早期 队列2（n = 275）由9 - 16岁的青少年男性和女性组成， 18.来自北卡罗来纳州查佩尔山大学、华盛顿圣路易斯大学和 伊利诺伊大学香槟分校将指导和咨询候选人的3个培训目标， 玛格丽特谢里丹博士& Adam米勒博士（联合小学导师），沿着卡伦鲁道夫 哲学博士、Deanna Barch博士，凯蒂·盖茨博士（科学顾问）和伊娃特尔泽博士还有琼·吕比 M.D.（顾问）。该奖项提供了必要的培训，成为一个独特的，跨学科的 研究者在临床，社会和发展神经科学的交叉。在谘询 导师，候选人将使用培训和研究的结果，以告知在未来的步骤， 候选人的研究计划，对儿童逆境，社会动机，和风险的STBs期间 青春期该奖项的培训和结果也将为未来的R 01提交提供信息。

PROJECT SUMMARY This goal of this K23 Mentored Patient-Oriented Research Career Development Award is for the candidate to gain expertise in childhood threat exposure, social motivation (SM), and risk for suicidal thoughts and behaviors (STBs). Childhood threat exposure increases risk for STBs by affecting brain functioning associated interpersonal stress. Adolescence is filled with interpersonal stress; yet, not all adolescents with childhood threat exposure experience STBs, indicating that additional factors exacerbate risk. Identifying additional factors that interact with threat to increase STBs is imperative for identifying novel suicide prevention target mechanisms. This project will identify whether SM represents an additional factor that moderates the link between childhood threat exposure and STBs. Training objectives for this award will include skill acquisition in: (1) Developmental psychopathology models of childhood threat exposure and SM, (2) Neurobiological and behavioral mechanisms of risk for STBs, and (3) Advanced intensive time series modeling of brain connectivity. Training will facilitate the ability to conduct a study characterizing self-report, brain, and behavioral measures of SM in adolescents (Aim 1) to examine whether maladaptive social motivation strengthens the link between threat exposure and STBs (Aim 2). A final exploratory Aim 3 will allow for a preliminary investigation into how puberty, biological sex, and age further moderate the interaction between threat exposure and SM on STBs. This study will leverage two R01 projects to test Aims in two Cohorts; Cohort 1 (n = 220) includes early adolescent females aged 9 – 16, while Cohort 2 (n = 275) consists of adolescent male and females aged 15- 18. Experts from the University of North Carolina at Chapel Hill, Washington University St. Louis, and the University of Illinois Urbana-Champaign will mentor and consult with the candidate on the 3 training goals of this project: Margaret Sheridan Ph.D. & Adam Miller Ph.D. (Co-primary mentors), along with Karen Rudolph Ph.D., Deanna Barch Ph.D., Katie Gates, Ph.D. (Scientific Advisors), and Eva Telzer, Ph.D. and Joan Luby, M.D. (Consultants). This award provides the necessary training to become a unique, transdisciplinary researcher at the intersection of clinical, social, and developmental neuroscience. In consultation with the mentors, the candidate will use the training and the results of the research to inform the next steps in the candidate’s program of research on childhood adversity, social motivation, and risk for STBs during adolescence. Training and results from this award will also inform future R01 submission.