Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors

青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响

• 批准号: 10785373
• 负责人: Andrea Pelletier Baldelli
• 金额: $ 18.5万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10785373
• 关键词: Adolescence; Adolescent; Affect; Age; Automobile Driving; Award; Behavior; Behavior assessment; Behavioral; Behavioral Mechanisms; Behavioral Paradigm; Brain; Cause of Death; Child Abuse and Neglect; Childhood; Clinical; Consult; Consultations; Corpus striatum structure; Cross-Sectional Studies; Data; Data Collection; Development; Doctor of Medicine; Doctor of Philosophy; Evaluation; Exhibits; Expenditure; Exposure to; Family; Feedback; Feeling suicidal; Female; Female Adolescents; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Illinois; Individual; Intervention; Interview; Investigation; Knowledge; Link; Longitudinal Studies; Male Adolescents; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Motivation; National Institute of Mental Health; Neurosciences; North Carolina; Parents; Pathway interactions; Patient Self-Report; Process; Psychopathology; Puberty; Punishment; Reporting; Research; Research Personnel; Rest; Risk; Risk Behaviors; Risk Factors; Role; Scientific Advances and Accomplishments; Self Assessment; Series; Severities; Social Interaction; Stress; Suicide; Suicide prevention; Symptoms; Testing; Time; Training; Training Support; Universities; Washington; Youth; aged; behavior measurement; biological sex; career; childhood adversity; cohort; community violence; experience; improved; multimodality; neural; neurobiological mechanism; neuroimaging; novel; peer; programs; recruit; sex; skill acquisition; skills; social; social stress; suicidal adolescent; suicidal behavior; suicidal risk

PROJECT SUMMARY This goal of this K23 Mentored Patient-Oriented Research Career Development Award is for the candidate to gain expertise in childhood threat exposure, social motivation (SM), and risk for suicidal thoughts and behaviors (STBs). Childhood threat exposure increases risk for STBs by affecting brain functioning associated interpersonal stress. Adolescence is filled with interpersonal stress; yet, not all adolescents with childhood threat exposure experience STBs, indicating that additional factors exacerbate risk. Identifying additional factors that interact with threat to increase STBs is imperative for identifying novel suicide prevention target mechanisms. This project will identify whether SM represents an additional factor that moderates the link between childhood threat exposure and STBs. Training objectives for this award will include skill acquisition in: (1) Developmental psychopathology models of childhood threat exposure and SM, (2) Neurobiological and behavioral mechanisms of risk for STBs, and (3) Advanced intensive time series modeling of brain connectivity. Training will facilitate the ability to conduct a study characterizing self-report, brain, and behavioral measures of SM in adolescents (Aim 1) to examine whether maladaptive social motivation strengthens the link between threat exposure and STBs (Aim 2). A final exploratory Aim 3 will allow for a preliminary investigation into how puberty, biological sex, and age further moderate the interaction between threat exposure and SM on STBs. This study will leverage two R01 projects to test Aims in two Cohorts; Cohort 1 (n = 220) includes early adolescent females aged 9 – 16, while Cohort 2 (n = 275) consists of adolescent male and females aged 15- 18. Experts from the University of North Carolina at Chapel Hill, Washington University St. Louis, and the University of Illinois Urbana-Champaign will mentor and consult with the candidate on the 3 training goals of this project: Margaret Sheridan Ph.D. & Adam Miller Ph.D. (Co-primary mentors), along with Karen Rudolph Ph.D., Deanna Barch Ph.D., Katie Gates, Ph.D. (Scientific Advisors), and Eva Telzer, Ph.D. and Joan Luby, M.D. (Consultants). This award provides the necessary training to become a unique, transdisciplinary researcher at the intersection of clinical, social, and developmental neuroscience. In consultation with the mentors, the candidate will use the training and the results of the research to inform the next steps in the candidate’s program of research on childhood adversity, social motivation, and risk for STBs during adolescence. Training and results from this award will also inform future R01 submission.

项目摘要 这个K23指导的以患者为导向的研究职业发展奖的目标是候选人 在儿童威胁暴露，社会动机（SM）以及自杀思想的风险和风险方面获得专业知识 行为（STB）。儿童威胁暴露通过影响大脑功能与与大脑功能相关的风险增加了STB的风险 人际压力。青少年充满了人际压力。但是，并非所有与童年的青少年 威胁暴露经历STB，表明其他因素加剧了风险。确定其他 与威胁增加STB相互作用的因素对于识别新型自杀预防目标至关重要 机制。该项目将确定SM是否代表调节链接的附加因素 在童年威胁暴露和STB之间。该奖项的培训对象将包括： （1）儿童威胁暴露和SM的发展心理病理学模型，（2）神经生物学和 STBS风险的行为机制和（3）大脑的先进密集型时间序列建模 连接性。培训将有助于进行表征自我报告，大脑和行为的研究能力 青少年中SM的度量（目标1），以检查适应不良的社会动机是否有效 在威胁暴露和STB之间（AIM 2）。最终的探索目标3将允许进行初步调查 进入青春期，生物性别和年龄如何进一步缓和威胁暴露与SM之间的相互作用 STBS。这项研究将利用两个R01项目在两个队列中测试目标。队列1（n = 220）包括早期 年龄9 - 16岁的青春期女性，而队列2（n = 275）由青少年男性和女性组成15-- 18。来自北卡罗来纳大学教堂山华盛顿大学圣路易斯大学的专家 伊利诺伊大学Urbana-Champaign大学将指导并与候选人有关3个培训目标的候选人 该项目：玛格丽特·谢里丹（Margaret Sheridan）博士＆Adam Miller博士（共同主要导师），以及卡伦·鲁道夫（Karen Rudolph） 博士学位，Deanna Barch Ph.D.，Katie Gates，Ph.D。 （科学顾问）和Eva Telzer博士和琼·卢比， 医学博士（顾问）。该奖项提供了必要的培训，以成为独特的跨学科 临床，社会和发育神经科学交集的研究人员。在与 候选人将使用研究和研究结果来告知下一步 候选人在儿童期广告，社交动机和STB的风险方面的研究计划 青少年。该奖项的培训和结果还将为未来的R01提交提供信息。