Measurement and modelling of sensory-motor interactions between fluid rheology and swallowing biomechanics

流体流变学和吞咽生物力学之间感觉运动相互作用的测量和建模

基本信息

  • 批准号:
    RGPIN-2014-06081
  • 负责人:
  • 金额:
    $ 2.19万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2014
  • 资助国家:
    加拿大
  • 起止时间:
    2014-01-01 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

The act of swallowing is one that most people take for granted. Whether we are drinking a glass of water, or savouring a favourite main course, we swallow, unaware that the successful transport of food or fluid through our mouths and throats involves a complex interaction between oro-pharyngeal sensory function and the sequenced contraction of more than 38 paired muscles in the upper aerodigestive tract. The biomechanics of swallowing must be fine-tuned to deal with a variety of different food and liquid textures, and rely on sensory information for this fine-tuning. Thin liquids are arguably the most challenging texture to swallow safely, because they flow fast and can easily be aspirated (enter the airway) if swallowing biomechanics are mistimed. A long-term goal of the research in my laboratory is to better understand how swallowing biomechanics vary across liquids with different viscosities and to determine how sensory awareness of fluid flow characteristics (rheology) influences this variation. Breakdowns in this process are part of dysphagia (swallowing impairment), which has significant consequences both for health and for quality of life. Over the next 5 years, we have the following short-term goals: a) To measure the rheological (flow) characteristics of a variety of fluid stimuli, including those used in the assessment and management of swallowing impairment, such as barium contrast media and thickened liquids. b) To measure human sensory discrimination ability for small differences in fluid rheology, to identify the smallest perceivable differences. c) To measure a variety of physiological swallowing signals (tongue-palate pressures, electromyography, ultrasound, videofluoroscopy) to characterize human patterns of motor variation in response to differences in fluid flow. d) To develop and validate radiographic image analysis techniques (and associated user-friendly tools, such as Image-J plug-ins) to quantify physiological differences in swallowing biomechanics in response to differences in fluid rheology. e) To use these data arising from these previous goals to build a mathematical model that accurately accounts for the variation of swallowing biomechanics across perceivable differences in fluid viscosity. Integral to this program of research is the interprofessional training of highly qualified personnel from the disciplines of engineering and speech-language pathology (S-LP). We are requesting funding to support trainees from both disciplines in research and applied training opportunities. This will foster improved understanding of instrumentation and measurement for the S-LPs, and of the application of engineering and measurement techniques to a physiological context (swallowing impairment) for the engineers. Ultimately, this program of research will provide a foundation of rigorous measurement and empirical evidence upon which advancements in several different fields related to the management of swallowing disability can be built. These include the refinement and development of rheologically modified fluids for use in assessment and management contexts; the development of devices and protocols for objectively measuring swallowing motor behaviours; and the development of training techniques to support precise and accurate measurement of swallowing behaviours by healthcare professionals.
吞咽动作是大多数人认为理所当然的动作。无论我们是喝一杯水,还是品尝最喜欢的主菜,我们都会吞咽,没有意识到食物或液体通过口腔和喉咙的成功输送涉及口咽感觉功能与上呼吸消化道中超过 38 对肌肉的顺序收缩之间复杂的相互作用。吞咽的生物力学必须进行微调,以应对各种不同的食物和液体质地,并依赖于感官信息来进行这种微调。稀薄液体可以说是安全吞咽最具挑战性的质地,因为它们流动速度快,如果吞咽生物力学不合时宜,很容易被吸入(进入气道)。我实验室研究的长期目标是更好地了解不同粘度液体的吞咽生物力学如何变化,并确定流体流动特性(流变学)的感官意识如何影响这种变化。这一过程的崩溃是吞咽困难(吞咽障碍)的一部分,这对健康和生活质量都有重大影响。在接下来的5年里,我们有以下短期目标:a)测量各种液体刺激的流变(流动)特征,包括用于吞咽障碍评估和管理的那些,例如钡造影剂和增稠液体。 b) 测量人类对流体流变学微小差异的感觉辨别能力,以确定最小的可感知差异。 c) 测量各种生理吞咽信号(舌腭压力、肌电图、超声、荧光电视透视),以表征响应流体流量差异的人类运动变化模式。 d) 开发和验证射线照相图像分析技术(以及相关的用户友好工具,例如 Image-J 插件),以量化吞咽生物力学中响应流体流变学差异的生理差异。 e) 使用这些先前目标产生的数据来建立一个数学模型,该模型可以准确地解释吞咽生物力学随液体粘度的可感知差异而变化的情况。该研究计划的一个组成部分是对工程和言语病理学(S-LP)学科的高素质人才进行跨专业培训。我们正在请求资金来支持两个学科的学员的研究和应用培训机会。这将促进工程师更好地理解 S-LP 的仪器和测量,以及工程和测量技术在生理环境(吞咽障碍)中的应用。最终,该研究计划将为严格的测量和经验证据提供基础,在此基础上可以在与吞咽障碍管理相关的几个不同领域取得进展。其中包括改进和开发用于评估和管理环境的流变改性流体;开发客观测量吞咽运动行为的设备和协议;以及开发培训技术以支持医疗保健专业人员精确测量吞咽行为。

项目成果

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Steele, Catriona其他文献

Tongue-pressure and hyoid movement timing in healthy liquid swallowing

Steele, Catriona的其他文献

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{{ truncateString('Steele, Catriona', 18)}}的其他基金

PGSB
PGSB
  • 批准号:
    244786-2001
  • 财政年份:
    2003
  • 资助金额:
    $ 2.19万
  • 项目类别:
    Postgraduate Scholarships
PGSB
PGSB
  • 批准号:
    244786-2001
  • 财政年份:
    2002
  • 资助金额:
    $ 2.19万
  • 项目类别:
    Postgraduate Scholarships
PGSB
PGSB
  • 批准号:
    244786-2001
  • 财政年份:
    2001
  • 资助金额:
    $ 2.19万
  • 项目类别:
    Postgraduate Scholarships

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