Structural and functional studies of rhomboid protease PARL (Presenillin-Associated Rhomboid-Like) in Parkinson's disease

菱形蛋白酶 PARL（早老素相关菱形样）在帕金森病中的结构和功能研究

• 批准号: 331238
• 负责人: Smithers Cameron C
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-12-01 至 2015-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331238&lang=en
• 关键词: Enzymatic Assay; Intramembrane Proteolysis; Membrane Protein; Mitochondria; Mitophagy; Parkinson'S Disease; Parl; Pink1; Rhomboid Protease; Signalling

Cell viability relies on a careful balance of fission and fusion of the mitochondria, the energy producing organelle. Disruption of this balance leads to cell death, as observed in the dopaminergic neurons in Parkinson’s Disease (PD). Mitochondrial fusion

细胞的生存依赖于线粒体分裂和融合的仔细平衡，线粒体是产生能量的细胞器。这种平衡的破坏会导致细胞死亡，就像帕金森病(PD)中观察到的多巴胺能神经元一样。线粒体融合