Structural and functional studies of rhomboid protease PARL (Presenillin-Associated Rhomboid-Like) in Parkinson's disease
Structural and functional studies of rhomboid protease PARL (Presenillin-Associated Rhomboid-Like) in Parkinson's disease
批准号:
331238
负责人:
Smithers Cameron C
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-12-01 至 2015-12-01
中文摘要
细胞活力依赖于线粒体(产生能量的细胞器)的裂变和融合的谨慎平衡。这种平衡的破坏导致细胞死亡,如在帕金森病(PD)的多巴胺能神经元中观察到的。线粒体融合
英文摘要
Cell viability relies on a careful balance of fission and fusion of the mitochondria, the energy producing organelle. Disruption of this balance leads to cell death, as observed in the dopaminergic neurons in Parkinson’s Disease (PD). Mitochondrial fusion
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