Human Ocular Surface Sensory Processing

人眼表面感觉处理

• 批准号: 183965-2013
• 负责人: Simpson, Trefford
• 金额: $ 2.11万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569676
• 关键词: Human; Ocular; Surface; Sensory; Processing

Human Ocular Surface Sensory Processing: The surface of the human eye is one of the most sensitive places on the body and yet little is understood about this sensitivity in humans. This proposal is for the continuation of a series of experiments to examine this, with a unique device that blows tiny amounts of a mixture of air and carbon dioxide onto the eye. This device enables us to measure the response in humans to pressure (a scratchy feeling), chemical (burning or stinging) and cold stimulation of the surface of the eye allowing us to to probe the function of those specific types of neural channels. The proposal is to perform a series of experiments to characterise the sensitivity of the whole exposed and hidden (under the lids) surface of the eye to determine what can just be detected, as well as what can be felt to be different (detection and discrimination thresholds). In addition, the response of the ocular surface with stimuli that are more noticeable (suprathreshold) will also be examined and I will tie the words used to describe sensations to the stimulation itself. These sensory processing maps of how the surface responds to different kinds of stimuli will be compared to new measures of the anatomy of the eye's surface (obtained particularly using a confocal microscopy and ocular coherence tomography). In addition we will begin to determine how processing develops in infants, it it changes in the aged and whether it differs in males and females. Finally, we will continue to examine what happens to the other structures of the eye (e.g., the blood vessels) when a painful stimulus is applied, in order to develop an understanding of the circuits on the eye's surface that respond to painful and innocuous stimuli. The long term goal of this research is to understand how we sense things at the surface of our eyes, develop better measurements of this sensing so that, eventually, we will be able to provide more effective tools for those trying to treat people suffering with uncomfortable and painful eyes.

人眼表面感觉处理：人眼表面是身体上最敏感的地方之一，但对人类的这种敏感性知之甚少。这项提议是为了继续进行一系列的实验来检验这一点，使用一种独特的装置，将少量的空气和二氧化碳的混合物吹到眼睛上。该设备使我们能够测量人类对眼睛表面的压力（发痒的感觉），化学物质（燃烧或刺痛）和冷刺激的反应，使我们能够探测这些特定类型的神经通道的功能。 该建议是进行一系列实验，以确定眼睛的整个暴露和隐藏（眼睑下）表面的敏感性，以确定什么可以检测到，以及什么可以感觉到不同（检测和辨别阈值）。此外，眼表对更明显的刺激（阈上刺激）的反应也将被检查，我将把用于描述感觉的词语与刺激本身联系起来。 这些表面如何对不同种类的刺激做出反应的感觉处理图将与眼睛表面解剖学的新测量进行比较（特别是使用共聚焦显微镜和眼相干断层扫描获得）。此外，我们将开始，以确定如何处理发展的婴儿，它的变化，在老年人和是否有不同的男性和女性。 最后，我们将继续研究眼睛的其他结构（例如，当施加疼痛刺激时，为了了解对疼痛和无害刺激做出反应的眼睛表面电路， 这项研究的长期目标是了解我们如何在眼睛表面感知事物，开发更好的测量方法，以便最终能够为那些试图治疗眼睛不适和疼痛的人提供更有效的工具。