The design and application of new classes of multistep transition metal catalyzed reaction

新型多步过渡金属催化反应的设计与应用

• 批准号: 184020-2009
• 负责人: Arndtsen, Bruce
• 金额: $ 6.56万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569685
• 关键词: design; application; new; classes; multistep

This research will examine the design of alternative methods to use transition metal catalysis in issues of importance to chemical synthesis. These range from pharmaceutically relevant product synthesis, new classes of polymers, environmentally friendly (Green) reactions, and efficient access to chiral compounds. The specific issues that will be examined are: One Step Synthesis: We propose to use metal catalysis to develop simple, "one step" methods to assemble biologically relevant core structures directly from available building blocks. Because of their efficiency, these will be not only be straightfoward to perform, but also minimize waste, and can prove useful for creating new variants of bio-active compounds. These reactions will both be developed, and applied to the construction of important pharmaceutically relevant products. Catalytic Multicomponent Polymerizations: We propose to develop catalytic approaches to assemble complex polymers in a similar fashion to high volume polymers: by in this case assembling several simple monomers together at once via catalysis (a multicomponent polymerization). This can provide a method to access complex polymers in a practical fashion. These studies will be directed towards generating new classes of conjugated polymers, as well as polymer libraries to tune their properties. Modular Approaches to Asymmetric Transition Metal Catalysis: While asymmetric catalysis provides an efficient route to construct chiral building blocks, the identification of the correct chiral ligand for high selectivity is a significant challenge, since each ligand must be synthesized. We propose to design an alternative to synthetic chiral ligands, which instead uses receptor ligands that can simply hydrogen bond with "non-synthetic" and chiral amino acids. These can be easily modified without synthesis, creating a system well suited to tune for high selectivity.

本研究将探讨在化学合成的重要问题中使用过渡金属催化的替代方法的设计。 这些范围从药物相关的产品合成，新型聚合物，环境友好（绿色）反应，并有效地获得手性化合物。 将审查的具体问题是： 一步合成：我们建议使用金属催化来开发简单的“一步”方法，直接从可用的构建模块组装生物相关的核心结构。 由于它们的效率，这些不仅可以直接执行，而且可以最大限度地减少浪费，并且可以证明用于创建生物活性化合物的新变体。 这些反应将被开发，并应用于重要的药学相关产品的构建。 催化多组分聚合：我们建议开发催化方法，以类似于高体积聚合物的方式组装复杂聚合物：在这种情况下，通过催化将几个简单的单体一次性组装在一起（多组分聚合）。 这可以提供一种以实用方式获得复杂聚合物的方法。 这些研究将针对产生新的共轭聚合物类别，以及聚合物库来调整其性能。 不对称过渡金属催化的模块化方法：虽然不对称催化提供了构建手性结构单元的有效途径，但由于每个配体都必须合成，因此识别正确的手性配体以实现高选择性是一个重大挑战。 我们建议设计一种替代合成手性配体，而不是使用受体配体，可以简单地氢键与“非合成”和手性氨基酸。这些可以很容易地修改，而无需合成，创造一个非常适合调整高选择性的系统。