New Organometallic Catalysts for Multistep Coupling Reactions

用于多步偶联反应的新型有机金属催化剂

• 批准号: RGPIN-2017-06706
• 负责人: Arndtsen, Bruce
• 金额: $ 7.72万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692909
• 关键词: New; Organometallic; Catalysts; Multistep; Coupling

Our research during the last 6 years has led to discoveries in several different areas of transition metal catalysis. These include:**** a) the observation that metal catalyzed aryl halide carbonylations can be used in a new direction: the assembly of high energy electrophiles (acid chlorides);**** b) the use of metal catalysis to convert of multiple available reagents in one step into products;**** c) an alternative approach to prepare conjugated polymers without a complex synthesis: a metal catalyzed multicomponent polymerization;**** d) new and modular classes of 1,3-dipoles for application in cycloaddition; and**** e) the use of weak forces such as ion pairing to design active and (enantio)selective metal catalysts.* *** Together, these suggest the potential to form products as diverse as complex pharmaceutical cores or advanced polymers from simple combinations of available reagents brought together at once, as well as new approaches to functionalize hydrocarbons. This proposal will develop this chemistry in three directions, including:*******Carbonylative Electrophile Synthesis Our discovery that palladium catalyzed aryl halide carbonylations can be used to synthesize acid chlorides shows that it is possible to use simple carbon monoxide not simply as a reagent, but as a compound that can drive the build-up of high energy products. In this proposal, we will examine the potential of exploiting this platform as a general method to synthesize acid chloride electrophiles or even super electrophiles, and to perform hydrocarbon functionalization into ketones, all driven by the reactivity of carbon monoxide.*******One Step Routes to Biologically Relevant Products We will build upon our recent research efforts to use metal catalysis to develop simple, one step methods to assemble biologically relevant core structures directly from available building blocks. Because of their efficiency, these reactions can be not only straightforward to perform, but also minimize waste, and can prove ideal for creating new variants of bio-active compounds. These efforts will include creating both new classes of these catalytic reactions, and the potential application of these to directly construct important pharmaceutical structures via catalysis.*******Multicomponent Polymerizations We have recently discovered a new method to assemble complex polymers in an efficient fashion: by coupling several simple monomers directly into a new polymer (a metal catalyzed multicomponent polymerization). This can provide an approach to form complex polymers in a practical manner, and will be directed towards generating new classes of conjugated polymers, modular methods to access polyamides, as well as the creation of novel polymer libraries to tune their properties.***

在过去的6年中，我们的研究在过渡金属催化的几个不同领域取得了发现。 其中包括：* a）观察到金属催化的芳基卤化物羰基化可以用于新的方向：高能亲电体（酰氯）的组装;* B）使用金属催化在一个步骤中将多种可用的试剂转化为产物;* c）制备共辄聚合物而无需复杂合成的替代方法：金属催化的多组分聚合;* d）用于环加成的新的和模块化类别的1，3-偶极子;和 * e）使用弱力如离子配对来设计活性和（对映体）选择性金属催化剂。 *** 总之，这些都表明有可能形成复杂的药物核心或先进的聚合物，从简单的组合，同时汇集在一起，以及新的方法来官能化烃的产品。 该提案将在三个方向上发展这种化学，包括：** 羰基亲电合成我们发现钯催化的芳基卤羰基化可用于合成酰氯，这表明可以使用简单的一氧化碳不仅仅作为试剂，而是作为一种可以驱动高能产物积累的化合物。 在本提案中，我们将研究利用该平台作为合成酰氯亲电试剂甚至超级亲电试剂的通用方法的潜力，并将烃官能化为酮，所有这些都由一氧化碳的反应性驱动。生物相关产品的一步路线我们将在我们最近的研究工作的基础上，使用金属催化来开发简单的一步方法，直接从可用的构建模块组装生物相关的核心结构。 由于它们的效率，这些反应不仅可以直接进行，而且可以最大限度地减少浪费，并且可以证明是创造生物活性化合物新变体的理想选择。 这些努力将包括创建这些催化反应的新类别，以及这些催化反应通过催化直接构建重要药物结构的潜在应用。多组分聚合我们最近发现了一种以有效方式组装复杂聚合物的新方法：通过将几个简单单体直接偶联成一种新聚合物（金属催化多组分聚合）。 这可以提供一种以实用的方式形成复杂聚合物的方法，并将致力于生成新类别的共轭聚合物，获得聚酰胺的模块化方法，以及创建新型聚合物库以调整其性能。