Towards Personalized Medicine: Molecular Imaging and Internal Radiotherapy

迈向个性化医疗：分子成像和内部放射治疗

• 批准号: 194512-2012
• 负责人: Celler, Anna
• 金额: $ 3.72万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569792
• 关键词: Towards; Personalized; Medicine; Molecular; Imaging

Recent progress in biology, chemistry and physics has open up unprecedented opportunities to advance the treatment of many diseases by employing radiopharmaceuticals in a "personalized medicine" paradigm. Nuclear medicine (NM) imaging techniques, such as PET and SPECT, are already well recognized for their molecular characteristics. Both techniques rely on the use of biologically active molecules, labeled with radioactive isotopes, to provide physicians with diagnostic information about the anatomy and/or physiology of patients. This not only helps to diagnose diseases, but also allows doctors to locate molecular receptor sites, study biological markers expressed by diseased cells, and monitor the presence and/or extent of specific disease processes. Additionally, in targeted internal radiotherapy (IRT), the same molecules labeled with therapeutic agents are used to deliver treatment to locations previously identified in diagnostic studies. The effectiveness of these medical procedures is, however, highly dependent both on the accuracy of localization of radiolabeled molecules and on the accuracy of quantitative measurement of their concentrations. In particular, to optimize IRT outcomes and minimize potential damage to healthy tissues, accurate dosimetry calculations must be performed. These calculations, however, remain very challenging due to the limited accuracy of radiotracer distribution measurements in routine imaging studies. As a result, dosimetry is often not performed or only crude estimates of delivered doses used. The main objective of the research program of my Medical Imaging Research Group (MIRG) is to use advanced physics, mathematics and computer science to develop new and improved methods for diagnostic and therapeutic nuclear medicine suitable for use both in everyday clinical practice and in medical and molecular research. The projects presented in this application utilize physics principles and build on past MIRG research to develop new techniques which should help to advance routine clinical practice to the personalized medicine era.

生物学、化学和物理学的最新进展为在“个性化医疗”范例中使用放射性药物推进许多疾病的治疗开辟了前所未有的机会。核医学成像技术，如PET和SPECT，由于其分子特性已经得到了广泛的认可。这两种技术都依赖于使用带有放射性同位素标记的生物活性分子，为医生提供有关患者解剖和/或生理的诊断信息。这不仅有助于疾病的诊断，而且使医生能够定位分子受体位点，研究病变细胞表达的生物标志物，并监测特定疾病过程的存在和/或程度。此外，在靶向内部放疗（IRT）中，使用标记有治疗剂的相同分子将治疗递送到先前在诊断研究中确定的部位。