The papaya mosaic virus platform; an innovative tool in nanotechnology

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Self-assembly of the papaya mosaic virus (PapMV) coat protein (CP) into a highly ordered and crystalline flexible rod is a complex process that involves several conformational changes and interacting domains within the CP subunits. We propose to elucidate the mechanism of self assembly of the coat protein of this virus. The long term objectives of this research program are: 1) to reinforce our understanding of the self-assembly process of the PapMV CP; 2) to unravel the mechanism of virus self-assembly in planta and; 3) to translate our understanding of the platform into topical antimicrobial applications for commercial production by specific engineering of the PapMV CP. The development of anti-microbial molecule could be used as an alternative to antibiotics. The novel nanoparticle could be used for topical use to improve (wound) healing by decreasing the risk of infectious contamination. Due to their increased stability, antimicrobial NLPs could probably be stored for long periods at room temperature and still provide long lasting anti-bacterial activity. The PapMV platform is a good example of a made-in-Canada nanoparticle that has potentially useful commercial antimicrobial applications that fulfill an unmet need for the Canadian and world populations seeking alternatives to antibiotics.