Analytical methods and analysis of in vivo toxicology of nanoparticles derived from the papaya-mosaic virus.

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Folia Biotech is a clinical-stage nanomedicine company working in the field of immunotherapy usingnanoparticles derived from papaya mosaic virus. En route toward clinical validation of their platformtechnology, they require further information on the blood circulation profile and biodistribution of their leadproduct.This proposal will be divided into two parts: 1) establishing a robust labeling method allowing tracking of theirnanoparticles in complex biological samples and 2) evaluating the circulation and biodistribution profiles oftheir proprietary technology. Together, these objectives will allow Folia to acquire the methods necessary tofurther understand how their nanoparticle interact with biological environments. This project will offertechnical knowledge and fundamental toxicology understanding. This will create value surrounding theproprietary technology, and foster the interest of pharmaceutical companies for collaborations.The academic lab involved in this project possesses accredited excellence in the labelling of nanoparticles andthe evaluation of their circulation profiles. By advancing the development of a nanomedicine technology thatcan be used for vaccination and immunotherapy, this project will create value for Canada, and contribute to thetraining of highly qualified personnel.