Cellular and network dynamics of medial temporal lobe memory structures

内侧颞叶记忆结构的细胞和网络动力学

• 批准号: 249861-2011
• 负责人: Dickson, Clayton
• 金额: $ 2.26万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=570747
• 关键词: Cellular; network; dynamics; medial; temporal

One of the most captivating mysteries of the brain concerns the purpose and role of sleep. That sleep represents a "resting" state of the body is understood, but the idea that it is a resting state of the brain is inconsistent with the continuing and often intense neural activity that occurs during sleep. One idea is that neural activity during sleep may be functioning to actively rewire neural connections and that this synaptic rewiring is relevant for memory processes. Our focus is on memories that require medial temporal lobe structures like the hippocampus (e.g. spatial memory) and the memory-enhancing role of particular patterns of spontaneous activity that appear during slow-wave sleep. It has been shown that slow-wave sleep is particularly important for improving hippocampal-dependent memories and we have identified a novel form of hippocampal slow-wave activity that may be a platform for inducing synaptic changes both within and across medial temporal lobe structures. This proposal outlines a study of this specific form of slow wave activity which has the aim of understanding how it arises, how it coordinates neural activity across large areas of the brain, and how it might influence synaptic changes that are relevant for memory. In addition, we will determine if changes in the pattern, density and coordination of this form of activity are indeed relevant for actual spatial memory enhancement. This research will be important for comprehending the role of sleep in complex memory processes.

大脑最令人着迷的奥秘之一是关于睡眠的目的和作用。 睡眠代表着身体的“休息”状态，这是可以理解的，但认为睡眠是大脑的休息状态的想法与睡眠期间发生的持续且经常强烈的神经活动不一致。一种观点认为，睡眠期间的神经活动可能起到积极地重新连接神经连接的作用，而这种突触重新连接与记忆过程有关。我们的重点是记忆，需要内侧颞叶结构，如海马（例如空间记忆）和记忆增强的作用，出现在慢波睡眠期间的自发活动的特定模式。 研究表明，慢波睡眠对于改善海马依赖性记忆特别重要，我们已经发现了一种新型的海马慢波活动形式，它可能是诱导内侧颞叶结构内和跨内侧颞叶结构突触变化的平台。 该提案概述了对这种特殊形式的慢波活动的研究，其目的是了解它是如何产生的，它如何协调大脑大区域的神经活动，以及它如何影响与记忆相关的突触变化。此外，我们将确定这种形式的活动的模式，密度和协调的变化是否确实与实际的空间记忆增强有关。这项研究对于理解睡眠在复杂记忆过程中的作用非常重要。