Transduction of wild type mice with AAV2-alpha-synuclein-GFP drives expression of alpha-synuclein in the brain stem region that controls muscle atonia during REM sleep.

用 AAV2-α-突触核蛋白-GFP 转导野生型小鼠可驱动脑干区域中 α-突触核蛋白的表达，从而控制快速眼动睡眠期间的肌肉无力。

• 批准号: 324334
• 负责人: McKenna Dillon
• 金额: $ 0.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=324334&lang=en
• 关键词: Alpha-Synuclein; Parkinson'S Disease; Rem Sleep; Rem Sleep Behavior Disorder; Subcoeruleus

Rapid eye movement (REM) sleep is the stage of sleep during which dreaming occurs and the body is paralyzed. Control of this paralysis relies on an area of the brain stem called the subcoeruleus (SubC). When the SubC stops functioning, paralysis is lost a

快速眼动（REM）睡眠是睡眠的一个阶段，在这个阶段，做梦发生，身体瘫痪。这种麻痹的控制依赖于脑干的一个称为蓝斑下（SubC）的区域。当SubC停止运作时，瘫痪就消失了。