Ubiquitous Biomedical Sensory Microsystems

申请更新资金的申请中提出的研究计划的长期目标是开发模拟和数字VLSI电路、架构和算法，以实现一次性、可穿戴和可植入微系统的新实现，以满足生物学和医学中尚未满足的关键泛在传感需求。我们的短期目标是设计、制作原型、进行实验表征，并在高影响力的应用中验证以下两个这样的感官微系统： 治疗神经系统疾病的全植入式无线脑接口 一次性无线电化学DNA分析微系统 提出的生物医学感官系统无处不在的原因有两个。首先，它们是微型的、廉价的、多功能的和自主操作的，这使得它们能够在临床环境内外得到广泛应用。其次，一组这样的传感器可以用来监测一些生命体征，并执行各种类型的自动化医疗诊断，在某些情况下，还可以进行自动化治疗。为了方便它们的使用，并消除昂贵的布线和包装，每个传感器都有一个完全无线的接口。 这个研究项目是跨学科的，具有协作性。这项资金申请的重点是作为这些无处不在的生物医学传感微系统的传感和计算核心的集成电路的新颖功能和性能优化。

The long-term objective of the research program proposed in this application for renewed funding is to develop analog and digital VLSI circuits, architectures and algorithms to enable novel implementations of disposable, wearable and implantable microsystems in order to address key unmet ubiquitous sensing needs in biology and medicine. Our short-term goal is to design, prototype, experimentally characterize and validate in high-impact applications the following two such sensory microsystems: Fully-implantable wireless brain interface for treatment of neurological disorders Disposable wireless electrochemical DNA analysis microsystem The reason for the ubiquity of the proposed biomedical sensory systems is two-fold. First, they are miniature, inexpensive, versatile and autonomously operating, which enables their widespread utilization, both within and outside of clinical settings. Second, a collection of such sensors can be used to monitor a number of vital signs, and perform various types of automated medical diagnostics and, in some cases, automated treatment. In order to facilitate their use, and to eliminate expensive wiring and packaging, each sensor has a fully wireless interface. This research program is cross-disciplinary and has a collaborative nature. The focus of this application for funding is on the novel functionality and performance optimization of integrated circuits which serve as the sensory and computational core of these ubiquitous biomedical sensory microsystems.