Protein evolution and protein disorder

蛋白质进化和蛋白质紊乱

• 批准号: 298245-2011
• 负责人: Harrison, Paul
• 金额: $ 2.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571460
• 关键词: Protein; evolution; protein; disorder

Proteins are made from sequences of amino acids linked together. Proteins perform many of the important functions in the cells of living organisms. They frequently have a modular structure, i.e., they are made of 'domains' that are combined in different ways to perform different functions. It is important to be able to understand the evolution of these component 'domains', so that we can find out what functions they perform. Some of these domains are 'disordered' in their normal functioning form (i.e., they do not have one, well-defined shape, but sample an ensemble of many different transient shapes). In the present proposal we will determine the evolutionary pressures acting on disordered regions in eukaryotes, so that we can better understand their functions, and improve how we label them in proteins.

蛋白质是由连接在一起的氨基酸序列组成的。蛋白质 在生物体的细胞中执行许多重要的功能。 它们通常具有模块化结构，也就是说，它们是由 以不同的方式组合以执行不同的功能。重要的是要成为 能够理解这些组件‘域’的演变，这样我们就可以找出 它们所执行的功能。这些结构域中的一些在正常的情况下是“无序的” 功能形式(即，它们没有一个定义良好的形状，而是样本 许多不同瞬变形状的集合)。 在目前的提案中，我们将确定作用于无序状态的进化压力 ，这样我们就可以更好地了解它们的功能，并改进 我们如何在蛋白质中标记它们。