Regulation of trance metal uptake and metabolism in freshwater fish

淡水鱼对金属的吸收和代谢的调节

• 批准号: 312017-2011
• 负责人: Niyogi, Som
• 金额: $ 1.75万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571670
• 关键词: Regulation; trance; metal; uptake; metabolism

The long-term objective of my research program is to study the molecular and physiological processes that govern essential and non-essential trace metal uptake and handling in freshwater animals, particularly fish. Over the next five years, I have proposed to study the three following topics. (1) Iron is an essential metal that is critical for all vertebrates including fish, and both iron deficiency and abundance in the body can cause adverse effects. However, very little is known about the mechanisms by which fish regulate iron uptake and metabolism. Fish are unique among the vertebrates, since they can absorb metals both via the gill and gut. I will examine the responses of key molecular and physiological processes involved in iron uptake and metabolism in fish during iron deficiency and overload. This is expected to enhance our understanding of how fish regulate their physiology to cope with the variable iron status in the environment. (2) Cadmium is a non-essential metal, which is very toxic to organisms. It is a ubiquitous aquatic contaminant, and recent evidence demonstrates that fish accumulate cadmium through calcium and iron uptake pathways both from water and diet. Hence, cadmium may cause toxicity by influencing the calcium and/or iron balance in fish. I will investigate how calcium and iron status in the water and diet affect cadmium uptake and metabolism in fish. This study could help in identifying sensitive physiological endpoints for assessing cadmium exposure and/or effects in fish living in metal-contaminated aquatic environments. (3) Iron nanoparticles are increasingly being used for environmental remediation, with the potential risk of adverse consequences to aquatic life. I will investigate how waterborne iron nanoparticle exposure affects physiological functions in fish. At present, there is a great paucity of knowledge on the impacts of nano-iron contamination in aquatic ecosystems, and my research is expected to provide important information in this regard.

我的研究计划的长期目标是研究控制淡水动物，特别是鱼的必需和非必需微量金属摄取和处理的分子和生理过程。今后五年，我提出要研究以下三个主题。 (1)铁是一种必需的金属，对包括鱼类在内的所有脊椎动物都是至关重要的，体内缺铁和过多都会造成不良影响。然而，人们对鱼类调节铁吸收和代谢的机制知之甚少。鱼在脊椎动物中是独一无二的，因为它们可以通过鳃和肠道吸收金属。我将研究鱼类在缺铁和超载期间铁吸收和代谢所涉及的关键分子和生理过程的反应。这有望增进我们对鱼类如何调节其生理以应对环境中可变的铁状态的理解。 (2)镉是一种非必需金属，对生物有很强的毒性。它是一种普遍存在的水生污染物，最近的证据表明，鱼类通过水和饮食中的钙和铁吸收途径积累镉。因此，镉可能通过影响鱼类体内的钙和/或铁平衡而造成毒性。我将研究水和饮食中钙和铁的状况如何影响鱼对镉的吸收和代谢。这项研究有助于确定敏感的生理终点，以评估生活在受金属污染的水环境中的鱼类的镉暴露和/或影响。 (3)纳米铁越来越多地用于环境修复，有可能对水生生物造成不良后果。我将研究暴露在水中的纳米铁颗粒如何影响鱼类的生理功能。目前，关于纳米铁污染对水生态系统的影响的知识非常匮乏，我的研究有望在这方面提供重要信息。