GPR54 regulates gene expression in a Gq/11 and beta-arrestin-dependent manner

GPR54 以 Gq/11 和 β-arrestin 依赖性方式调节基因表达

• 批准号: 327334-2011
• 负责人: Babwah, Andy
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571990
• 关键词: GPR54; regulates; gene; expression; Gq

Receptors are protein molecules expressed by all cells. Their job is to detect various stimuli, such as light and odor that the cell is exposed to and to convert these stimuli into a "language" the cell understands and can respond to appropriately. Failure to do so can result in the death of the cell. Despite decades of research, we are still unraveling how receptors convey these messages to the cell. In our case we are specifically interested in a receptor called GPR54. GPR54 regulates the reproductive capacity of animals, including humans. Recently, we determined that GPR54 uses two mechanisms to convey messages to cells. It was previously thought that only one of these two mechanisms might have instructed the cell to trigger changes in its gene expression; an act that ensures cell survival. However, we have evidence that the second mechanim also has a similar effect and it is critical we gain a more detailed insight into this. We believe that by understanding these mechanims in detail, we can develop novel livestock research programmes.

受体是所有细胞都表达的蛋白质分子。它们的工作是检测各种刺激，