GPR54 regulates gene expression in a Gq/11 and beta-arrestin-dependent manner

GPR54 以 Gq/11 和 β-arrestin 依赖性方式调节基因表达

• 批准号: 327334-2011
• 负责人: Babwah, Andy
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571990
• 关键词: GPR54; regulates; gene; expression; Gq

Receptors are protein molecules expressed by all cells. Their job is to detect various stimuli, such as light and odor that the cell is exposed to and to convert these stimuli into a "language" the cell understands and can respond to appropriately. Failure to do so can result in the death of the cell. Despite decades of research, we are still unraveling how receptors convey these messages to the cell. In our case we are specifically interested in a receptor called GPR54. GPR54 regulates the reproductive capacity of animals, including humans. Recently, we determined that GPR54 uses two mechanisms to convey messages to cells. It was previously thought that only one of these two mechanisms might have instructed the cell to trigger changes in its gene expression; an act that ensures cell survival. However, we have evidence that the second mechanim also has a similar effect and it is critical we gain a more detailed insight into this. We believe that by understanding these mechanims in detail, we can develop novel livestock research programmes.

受体是由所有细胞表达的蛋白质分子。他们的工作是检测各种刺激， 例如细胞所接触的光和气味，并将这些刺激转化为“语言”， 细胞能够理解并做出适当的反应。如果不这样做，可能会导致细胞死亡。尽管经过了几十年的研究，我们仍在解开受体如何将这些信息传递给细胞的谜团。在我们的案例中，我们对一种名为GPR 54的受体特别感兴趣。GPR 54调节包括人类在内的动物的生殖能力。最近，我们确定GPR 54使用两种机制向细胞传递消息。以前认为这两种机制中只有一种可能指示细胞触发其基因表达的变化;这一行为确保了细胞的存活。然而，我们有证据表明第二种机制也有类似的效果，关键是我们要对此有更详细的了解。我们相信，通过详细了解这些机制，我们可以开发新的牲畜研究计划。