Deciphering alternative functions of B lymphocytes

破译 B 淋巴细胞的替代功能

• 批准号: 340955-2010
• 负责人: Lapointe, Réjean
• 金额: $ 2.91万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572186
• 关键词: Deciphering; alternative; functions; lymphocytes

Deciphering alternative functions of B lymphocytes - Réjean LAPOINTE The immune system is responsible for helping our body to respond against aggressors. For long time, it was believed that B lymphocytes have mostly a central role in antibody production. However, in addition to this important goal, we now have more information on additional alternative functions of B lymphocytes, as they may also produce several molecules important for the communication between immune cells (called cytokines) and they have the capacity to present pieces of aggressors to other cells of the immune system. However, how these functions are regulated has not been fully defined. We have identified an array of genes and proteins that may be involved in the control of these functions. In this research program, we will characterize some molecular and cellular events controlling alternative functions. Specifically, we have tools in my laboratory which will allow us to remove the gene we have identified. Once these are absents, we will evaluate the capacity of B lymphocytes to produce cytokines. Also, we will evaluate how the capacity of presenting aggressors is affected by the modulation of these potential control genes, which may act as on/off switches. Impact and relevance : Thus, this is essentially a research program oriented to the understanding of the control mechanisms of alternative B cells functions, different from antibody production, and to the training of highly-qualified personnel (HQP), which is within the objective of the Discovery grant program. As long-term objectives, we propose to bridge this gap in knowledge by identifying genes/proteins involved in the regulation of alternative B cell functions, by understanding their mechanisms of action, and to learn more about the biology of B lymphocytes, as we succeeded in the past.

解读B淋巴细胞的替代功能- Réjean LAPOINTE 免疫系统负责帮助我们的身体对侵略者做出反应。长期以来，人们认为B淋巴细胞在抗体产生中起主要作用。然而，除了这个重要的目标，我们现在有更多关于B淋巴细胞的其他替代功能的信息，因为它们也可以产生几种对免疫细胞之间的通信很重要的分子（称为细胞因子），并且它们有能力将攻击者的片段呈递给免疫系统的其他细胞。然而，这些职能如何管理尚未得到充分界定。我们已经确定了一系列可能参与控制这些功能的基因和蛋白质。在这项研究计划中，我们将描述一些控制替代功能的分子和细胞事件。 具体地说，我们实验室里有工具，可以让我们移除我们已经识别的基因。一旦这些缺失，我们将评估B淋巴细胞产生细胞因子的能力。此外，我们将评估如何提出侵略者的能力是受这些潜在的控制基因，这可能会作为开/关开关的调制。 影响和相关性：因此，这基本上是一个研究计划，旨在了解替代B细胞功能的控制机制，不同于抗体生产，并培训高素质的人员（HQP），这是在发现资助计划的目标。作为长期目标，我们建议通过识别参与调节替代B细胞功能的基因/蛋白质，通过了解其作用机制，并了解更多关于B淋巴细胞的生物学知识来弥补这一差距，因为我们在过去取得了成功。