Deciphering alternative functions of B lymphocytes

破译 B 淋巴细胞的替代功能

• 批准号: RGPIN-2016-05376
• 负责人: Lapointe, Réjean
• 金额: $ 2.26万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629193
• 关键词: Deciphering; alternative; functions; lymphocytes

B lymphocytes/cells are very important in the immune response and their main role is to produce antibodies. While the mechanisms regulating B lymphocyte activation leading to antibody production are well understood, those involved in key alternative B cell functions are poorly defined, particularly cytokine production and antigenic presentation. Also, B cells sometimes infiltrate tissues and form alternative lymphoid structures (ALS; normally found in specialized lymphoid organs) in response to various environmental stimuli (stress, inflammation, etc.), and the roles of ALS in normal tissues are unclear. ALS formation is a biological phenomenon, important for increasing the efficiency of microbe sampling by naive lymphocytes. To date, B lymphocytes have been studied mostly in animal models and need to be characterized in humans. Addressing this challenge represents the objective in the current NSERC proposal.

B淋巴细胞/细胞在免疫应答中非常重要，其主要作用是产生抗体。虽然调节B淋巴细胞活化导致抗体产生的机制已被充分理解，但参与关键替代B细胞功能的机制定义不清，特别是细胞因子产生和抗原呈递。此外，B细胞有时会浸润组织并形成替代性淋巴结构（ALS;通常见于专门的淋巴器官）以响应各种环境刺激（应激、炎症等），ALS在正常组织中的作用尚不清楚。ALS形成是一种生物学现象，对于通过幼稚淋巴细胞增加微生物取样的效率很重要。迄今为止，B淋巴细胞主要在动物模型中进行研究，需要在人体中进行表征。应对这一挑战是当前NSERC提案的目标。