Neural noise in human cognitive ageing and reserve

人类认知衰老和储备中的神经噪声

• 批准号: FT230100658
• 负责人: Dr Mitchell Goldsworthy
• 金额: $ 67.86万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-04-01 至 2028-03-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100658
• 关键词: Neural; noise; human; cognitive; ageing

Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleability of neural noise. This will be delivered by novel combinations of electrophysiology, neuroimaging and non-invasive brain stimulation. Benefits extend from developing neural markers for measuring cognitive reserve to new strategies for building resilience to age-related cognitive decline.

与神经噪声相关的神经噪声增加会降低大脑中的信息传递，并导致认知功能减弱。然而，有了认知储备，有些人能够在晚年保持健康的功能。该项目旨在研究神经噪声对大脑连接，认知性能和储备的影响，推进健康认知老化的神经生理学和神经噪声的可塑性的突破性工作。这将通过电生理学、神经成像和非侵入性脑刺激的新组合来实现。其益处从开发用于测量认知储备的神经标记物扩展到建立对与年龄相关的认知衰退的恢复力的新策略。