"Brain mechanisms of nociceptive and non-nociceptive motor reflex regulation during sensory, motor and cognitive tasks."

“感觉、运动和认知任务期间伤害性和非伤害性运动反射调节的大脑机制。”

• 批准号: 402176-2012
• 负责人: Piché, Mathieu
• 金额: $ 2.33万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573184
• 关键词: Brain; mechanisms; nociceptive; non; motor

BRAIN MECHANISMS OF NOCICEPTIVE AND NON-NOCICEPTIVE MOTOR REFLEX REGULATION DURING SENSORY, MOTOR AND COGNITIVE TASKS. The spinal cord is one of the first relays of the central nervous system to receive somatosensory input from the periphery. This information is sent to the brain and may evoke perception, emotions, physiological responses, cognitive processes and behaviours. However, the brain exerts a powerful control over incoming information from the periphery and spinal cord. Indeed, several regions of the brain send descending commands that can block or amplify the transmission of peripheral information and associated motor reflexes, produced by the spinal cord. These bidirectional interactions between the spinal cord and the brain are at the core of the present proposal. Using innovative electrophysiological and brain imaging methods, the present research program will investigate which regions and which functions of the brain are involved in the encoding and regulation of two types of spinal motor reflexes, the H-reflex (evoked by innocuous stimulations) and the RIII-reflex (evoked by noxious stimulations). In addition, brain mechanisms allowing inhibition of spinal motor reflexes during motor suppression and analgesia will be examined. Altogether, these experiments will further our understanding of how the brain computes information related to spinal motor reflexes and how it acts on them to regulate motor responses and pain. In addition to benefit to the fields of pain and motor control, this work will provide scientific bases for common interventions that are used to induce analgesia, including counter-irritation (the pain-inhibit-pain phenomenon) and manipulation of attention.

感觉、运动和认知任务中伤害性和非伤害性运动反射调节的脑机制 脊髓是中枢神经系统接收来自外周的躯体感觉输入的第一中继之一。这些信息被发送到大脑，并可能引起感知，情绪，生理反应，认知过程和行为。然而，大脑对来自外周和脊髓的传入信息施加强大的控制。事实上，大脑的几个区域发送下行命令，可以阻止或放大脊髓产生的外围信息和相关运动反射的传输。脊髓和大脑之间的双向相互作用是本提案的核心。利用创新的电生理和脑成像方法，本研究计划将调查哪些区域和大脑的哪些功能参与两种类型的脊髓运动反射的编码和调节，H反射（由无害刺激引起）和RIII反射（由有害刺激引起）。此外，将检查在运动抑制和镇痛期间允许抑制脊髓运动反射的脑机制。总而言之，这些实验将进一步加深我们对大脑如何计算与脊髓运动反射相关的信息以及如何作用于它们以调节运动反应和疼痛的理解。除了有利于疼痛和运动控制领域，这项工作将提供用于诱导镇痛的常见干预措施的科学基础，包括反刺激（疼痛抑制疼痛现象）和注意力操纵。