BRAIN STEM MECHANISMS MEDIATING THE NOCICEPTIVE PRESSOR RESPONSE

调节伤害性压力反应的脑干机制

基本信息

  • 批准号:
    6302096
  • 负责人:
  • 金额:
    $ 19.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-01-01 至 2000-12-31
  • 项目状态:
    已结题

项目摘要

The goal of this proposal is to determine the role of the lateral parabrachial nucleus (LPBN) in mediating the cardiovascular responses to pain. Noxious stimulation typically elicits increases in arterial blood pressure and heart rate. These responses are mediated by nociceptive and cardiovascular centers in the brain stem. Recent anatomical and electrophysiological studies point to the LPBN as the major projection site for nociceptive inputs from lamina I and lamina II neurons in the spinal cord and the spinal trigeminal sensory nucleus in medulla. Moreover calcitonin gene-related peptide (CGRP) and substance P (SP), neuropeptides prominently involved in sensory afferent and nociceptive pathways, are present in LPBN and have been implicated in ascending pain pathways. These studies will use single cell electrophysiological recording techniques, recordings of arterial pressure, heart rate and sympathetic nerve activity, and functional neuroanatomy (c-fos) to determine the role of the LPBN in mediating the nociceptive pressor response by stimulating the trigeminal afferent system which has a discrete termination site in caudal medulla and well defined projection pathways to LPBN. The influence of the solitary tract nucleus (NTS) will also be examined, though existing data suggest a secondary role for NTS in this process. Finally, the interactions of baroreceptor afferent signals with noxious inputs will be determined at LPBN and at the rostral ventrolateral medulla (RVLM), the medullary sympathetic outflow site for the pressor response. The trigeminal afferent system mediates a number of important clinical pain syndromes, including migraine headache, the headache of arachnoid hemorrhage, trigeminal neuralgia, temporal mandibular joint pain and corneal and oral cavity pain. Thus, a better understanding of the central neural mechanisms mediating cardiovascular responses to noxious trigeminal stimulation may ultimately lead to new management strategies for patients with these clinical syndromes. In addition, these findings will contribute to the basic understanding of the central link between nociceptive afferent signals and cardiovascular regulation.
本提案的目标是确定横向的作用

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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Robert B Felder其他文献

Robert B Felder的其他文献

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{{ truncateString('Robert B Felder', 18)}}的其他基金

Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
  • 批准号:
    8204899
  • 财政年份:
    2010
  • 资助金额:
    $ 19.28万
  • 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
  • 批准号:
    8399052
  • 财政年份:
    2010
  • 资助金额:
    $ 19.28万
  • 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
  • 批准号:
    8038587
  • 财政年份:
    2010
  • 资助金额:
    $ 19.28万
  • 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
  • 批准号:
    8589602
  • 财政年份:
    2010
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
  • 批准号:
    8758110
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
  • 批准号:
    6671631
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
  • 批准号:
    8389884
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
  • 批准号:
    8197258
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokine and sympathetic drive in heart failure
心力衰竭中的细胞因子和交感神经驱动
  • 批准号:
    6704843
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
  • 批准号:
    7751935
  • 财政年份:
    2003
  • 资助金额:
    $ 19.28万
  • 项目类别:

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BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE
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  • 批准号:
    2668745
  • 财政年份:
    1996
  • 资助金额:
    $ 19.28万
  • 项目类别:
BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE
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  • 财政年份:
    1996
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    $ 19.28万
  • 项目类别:
BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE
口渴和盐食欲中的压力感受器和激素
  • 批准号:
    2378847
  • 财政年份:
    1996
  • 资助金额:
    $ 19.28万
  • 项目类别:
BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE
口渴和盐食欲中的压力感受器和激素
  • 批准号:
    2232618
  • 财政年份:
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    $ 19.28万
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BARORECEPTORS AND HORMONES IN THIRST AND SALT APPETITE
口渴和盐食欲中的压力感受器和激素
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  • 财政年份:
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    $ 19.28万
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