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Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health

Obesity and nutritional programming of the paternal sperm epigenome: effects on offspring development and health
父亲精子表观基因组的肥胖和​​营养规划：对后代发育和健康的影响
批准号：
321141
负责人：
Kimmins Sarah
金额：
$78.47万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-03-01 至 2020-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=321141&lang=en
关键词：
Developmental Origins Of Adult Disease Dietary Folate Environmental Programming Epigenomics Histones Paternal Disease Transmission Paternal Obesity Reproduction Spermatogenesis Transgenerational Inheritance

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英文摘要
The impact of diet and body condition on the father's reproductive health and that of his offspring has been relatively under-explored and under-emphasized. Over the past two decades male fertility is declining as measured by lowered sperm counts, increas
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Identifying molecular mechanisms underlying the regulatory role of sperm chromatin in embryo development and adult disease
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