Sustainable, continuous chemical manufacturing using micro flow reactor technology

使用微流反应器技术进行可持续、连续的化学制造

• 批准号: 445703-2012
• 负责人: Organ, Michael
• 金额: $ 23.68万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=575067
• 关键词: Sustainable; continuous; chemical; manufacturing; using

Many business sectors have moved production to a 'just-in-time' operation that offers many practical advantages that lead to improved efficiency and cost savings. Fine-chemical synthesis, such as the preparation of drugs, may have the most to be gained by moving to such a format and yet chemical manufacturing continues to be done following traditional scale-up strategies with the goal of producing single batches of large quantities of final material. The build up and maintenance of large chemical inventories is a serious potential health and environmental concern and creates logistical and quality control issues. For such approaches to be adopted, it would take a significant shift in mind set in industry and the invention of pioneering new technology. Flowed chemical synthesis is currently being evaluated as the technological platform upon which sustained chemical manufacturing will be built. The premise is that reactions can be performed on a small scale at any one point in time in small diameter reactors (chips or tubes). This will allow for rapid reaction condition assessment and optimization literally on single drops of effluent from the reactor, thus drastically reducing environmental impact. Once optimized conditions are achieved, the process can be run for as long as is necessary to generate the desired amount of material. If much larger quantities are required, the reactions can be flowed in parallel, but again it is produced now only in the quantities necessary to meet need eliminating large-scale chemical storage. The PI of this initiative has developed pioneering flow technology using microwave irradiation to rapidly drive reactions to completion in the relatively short time that they reside in the flow reactor. He has assembled a diverse team of chemical, computer, and electronics engineers and synthetic and analytical chemists to integrate the flow microwave reactor into a standalone synthesis plant capable of reaction optimization using artificial intelligence with complete computer control. This new technology, which can operate at very high temperatures and pressures as is necessary, will provide a conceptually unique approach to chemical synthesis and a solution for sustained chemical manufacturing in Canada and beyond.

许多商业部门已将生产转移到“准时”运营，提供了许多实用的 带来更高效率和成本节约的优势。精细化学合成、制备等 通过转向这种形式和化学制造，可能会获得最大的好处 继续遵循传统的扩大战略，目标是生产单个批次的大型 最终材料的数量。大量化学品库存的积累和维护是一个严重的潜在问题 健康和环境问题，并造成后勤和质量控制问题。对于这样的方法， 如果被采用，这将需要工业观念的重大转变和开创性的新发明 技术流动化学合成目前被评估为技术平台，在其上 建设可持续发展的化工制造业。前提是反应可以在小范围内进行 在小直径反应堆(芯片或管子)中的任何一个时间点。这将允许快速反应条件 从字面上评估和优化反应器的单滴出水，从而大大减少 对环境的影响。一旦达到优化的条件，流程就可以一直运行下去 产生所需数量的材料所必需的。如果需要大得多的量，反应可以 是平行流动的，但同样地，现在只生产满足消除需求所需的数量 大规模的化学品储存。这一倡议的PI开发了开创性的流动技术，使用 微波辐射使反应在相对较短的时间内快速完成 流动反应器。他组建了一支由化学、计算机、电子工程师和合成材料组成的多元化团队 和分析化学家将流动微波反应堆集成到一个独立的合成工厂中，该工厂能够 反应优化使用人工智能和完全的计算机控制。这项新技术，它 可以根据需要在非常高的温度和压力下运行，将在概念上提供独特的 化学合成的方法和加拿大及其他地区持续化学制造的解决方案。