Contribution of pathoadaptive mutations to antibiotic resistance development in chronic lung infections of Pseudomonas aeruginosa

铜绿假单胞菌慢性肺部感染中病理适应性突变对抗生素耐药性发展的贡献

• 批准号: 320290
• 负责人: Poole Keith R
• 金额: $ 51.27万
• 依托单位: Queen's University (Kingston, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=320290&lang=en
• 关键词: Antibiotic Resistance; Chronic Infection; Mutation; Pseudomonas Aeruginosa; Stress Response

Pseudomonas aeruginosa is a bacterium that causes severe, long-term (i.e. chronic) and often lethal infections in humans with chronic lung disease. The organism is innately resistant to many antibiotics and often develops what might be termed high-level a

铜绿假单胞菌是一种细菌，可导致慢性肺病患者严重、长期（即慢性）且常常致命的感染。该生物体对许多抗生素具有天生的抗药性，并且经常产生所谓的高水平抗生素。