Real-Time In Vivo Oral Pathology for Clinical Decision Making

用于临床决策的实时体内口腔病理学

• 批准号: 462490-2014
• 负责人: MacAulay, Calum
• 金额: $ 3.74万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=576920
• 关键词: Real; Time; Vivo; Oral; Pathology

We propose to provide new non-invasive optical imaging technology for guiding clinical decisions in the diagnosis and management of oral cancer. This new technology is called optical coherence tomography (OCT) and is analogous to ultrasound imaging except light is used as the imaging signal instead of sound. OCT can provide 3-dimensional images of tissue with resolution approaching histology. Currently, there is no OCT instrument specialized for imaging oral lesions. We propose to build such an instrument that will provide clinicians unprecedented detailed bedside views of oral tissue. Annually, oral cancer is diagnosed in 4100 Canadians and results in 1150 deaths. On the diagnostic front, determining the correct course of treatment for a patient with a suspicious oral lesion requires biopsy and diagnosis by a pathologist. However, the choice of biopsy location is not always obvious, and for larger lesions clinicians often need to take multiple biopsies to try to ensure sampling of the most severe pathology. This incomplete sampling means that the most severe pathology may be overlooked, leading to misdiagnosis. It is hoped that our OCT instrument will enable clinicians to find the most severe pathological site directly, necessitating only a single biopsy while ensuring accurate diagnosis. From the oral cancer management perspective, once oral cancer has been identified, surgical removal is usually the best curative treatment option. The challenge, however, is to determine where are the boundaries of the cancer to ensure precise surgical removal of the entire tumour. We hope that our OCT instrument will provide an additional tool for surgeons to accurately identify the boundary of the tumour so that it can be completely excised to prevent cancer recurrence. If successful, these oral cancer OCT applications will improve patient care and healthcare efficiency by reducing biopsies and ensuring accurate diagnosis, and by preventing cancer recurrence.

我们建议提供新的非侵入性光学成像技术，用于指导诊断和治疗中的临床决策。 口腔癌的治疗这项新技术被称为光学相干断层扫描（OCT），类似于 除了光之外的超声成像被用作成像信号而不是声音。OCT可以提供以下的三维图像： 分辨率接近组织学的组织。目前，还没有专门用于口腔病变成像的OCT仪器。我们 我建议建立这样一个仪器，将提供临床医生前所未有的详细的口腔组织床边视图。 每年有4100名加拿大人被诊断出患有口腔癌，导致1150人死亡。在诊断方面，确定 对患有可疑口腔病变的患者的正确治疗过程需要由病理学家进行活组织检查和诊断。 然而，活检位置的选择并不总是显而易见的，对于较大的病变，临床医生通常需要采取多个 活组织检查，以确保最严重的病理取样。这种不完整的抽样意味着， 病理可能被忽视，导致误诊。我们希望我们的OCT仪器能够使临床医生找到 最严重的病理部位直接，只需要一个单一的活检，同时确保准确的诊断。 从口腔癌管理的角度来看，一旦口腔癌已确定，手术切除通常是最好的 治愈性治疗选择。然而，挑战在于确定癌症的边界在哪里，以确保精确的 手术切除整个肿瘤。我们希望我们的OCT仪器将为外科医生提供额外的工具， 准确识别肿瘤的边界，以便完全切除肿瘤，防止癌症复发。如果 成功的话，这些口腔癌OCT应用将通过减少活检和 确保准确诊断，并防止癌症复发。