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Copper-Mediated Carbon-Carbon Bond Formation Reactions with Heterocyclic Compounds

Copper-Mediated Carbon-Carbon Bond Formation Reactions with Heterocyclic Compounds
铜介导的杂环化合物碳-碳键形成反应
批准号：
485466-2015
负责人：
Lundgren, Rylan
金额：
$1.82万
依托单位：
University of Alberta
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-01-01 至 2016-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584979
关键词：
CopperMediatedCarbonBondFormation

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英文摘要
Heterocyclic organic compounds are prevalent in bioactive molecules such as pharmaceuticals and agrochemicals. In order to prepare highly functionalized heterocyclic compounds, expensive and non-abundant transition metals such as rhodium and palladium are often employed to build up and diversify these scaffolds. We have developed a mild and selective copper-mediated process that forms carbon-carbon bonds and can be used to prepared functionalized aromatic and heteroaromatic molecules. This proposal aims to extend this methodology to targets that are of particular interest to SV ChemBioTech in order to streamline synthesis and reduce production costs.
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