Selective Catalytic Hydrogenation and Functionalization of Polyenes

多烯的选择性催化氢化和官能化

• 批准号: 556312-2020
• 负责人: Lundgren, Rylan
• 金额: $ 4.24万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706265
• 关键词: Selective; Catalytic; Hydrogenation; Functionalization; Polyenes

The goal of this research collaboration is to develop new chemical processes and to understand how feedstock small molecules can be converted into high value products by catalysis. Three distinct transformations of practical and fundamental importance are targeted. Each target poses a challenge to known methods in homogenous catalysis. The products sought to be made can readily undergo a myriad of side-reactions (over reduction, poly addition, isomerization), thus a high level of kinetic selectivity must be achieved by tailored reaction conditions and transition metal catalysts. The successful development of these processes should lead to more broad applications in sustainable chemical manufacturing. We plan a similar approach to the individual processes, consisting of initial broad screening of reaction conditions and catalysts to discover "hit" conditions followed by more careful reaction optimization and catalyst structure-reactivity studies, and finally demonstration of process scalability and generality.

这项研究合作的目标是开发新的化学工艺，并了解如何通过催化将原料小分子转化为高价值产品。有针对性地提出了三个具有实际和根本重要性的不同转变。每个目标都对均相催化中的已知方法提出了挑战。要制备的产物可以容易地经历无数副反应（过度还原、聚加成、异构化），因此必须通过定制的反应条件和过渡金属催化剂来实现高水平的动力学选择性。这些工艺的成功开发应能在可持续化学品制造中得到更广泛的应用。我们计划一个类似的方法，以个别的过程，包括初步广泛筛选的反应条件和催化剂，以发现“命中”的条件下，随后进行更仔细的反应优化和催化剂的结构-反应性的研究，并最终证明过程的可扩展性和通用性。