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Studying the Dynamics and Allosteric Regulation of Bacterial Protein Degradation Machinery by Solution NMR: Implications for Antibacterial Resistance

Studying the Dynamics and Allosteric Regulation of Bacterial Protein Degradation Machinery by Solution NMR: Implications for Antibacterial Resistance
通过溶液核磁共振研究细菌蛋白质降解机制的动力学和变构调节:对抗菌素耐药性的影响
批准号:
338942
负责人:
Vahidi Siavash
金额:
$9.83万
依托单位:
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-11-01 至 2018-11-01

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中文摘要
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英文摘要
Many chronic and relapsing infections are caused by antibiotic-resistant subpopulations of bacteria. Data from the World Health Organization (WHO) indicate that infections arising from these dormant variants of otherwise regular pathogens are increasing a
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Disrupting the Pathogens' Communication Lines: The Next Frontier in Combating Antimicrobial Resistance
  • 批准号:
    492393
  • 项目类别:
  • 资助金额:
    $0.15万
  • 财政年份:
    2023
  • 负责人:
    Vahidi Siavash
  • 依托单位:
Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia
  • 批准号:
    489309
  • 项目类别:
    Operating Grants
  • 资助金额:
    $83.32万
  • 财政年份:
    2023
  • 负责人:
    Vahidi Siavash
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Development of boron-based inhibitors of the mitochondrial ClpXP protease to combat AML
  • 批准号:
    472460
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Vahidi Siavash
  • 依托单位:
The Bhagirath Singh Early Career Prize in Infection and Immunity: Mechanisms of Allosteric Regulation of M. tuberculosis Proteasome Function
  • 批准号:
    446144
  • 项目类别:
    Operating Grants
  • 资助金额:
    $0.91万
  • 财政年份:
    2020
  • 负责人:
    Vahidi Siavash
  • 依托单位:
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