Sex and the Ageing Heart: The molecular basis for the functional decline and development of a novel therapeutic target

性与衰老的心脏：功能衰退的分子基础和新型治疗靶点的发展

• 批准号: 339909
• 负责人: Pyle Glen W
• 金额: $ 10.88万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339909&lang=en
• 关键词: Ageing; Capz; Heart; Myofilament; Sex; Z-Disc

Females have lower rates of heart failure compared to age-matched males throughout most of their life. However, after menopause the risk for heart failure in women rises until the difference between the sexes disappears by age 80. Ageing itself in an inde

与同龄男性相比，女性在一生中的大部分时间里，心力衰竭的发生率较低。然而，绝经后，女性患心力衰竭的风险会上升，直到 80 岁时性别差异消失。