Understanding the interaction between methionine metabolism and epigenetics in cancer

了解癌症中蛋氨酸代谢与表观遗传学之间的相互作用

• 批准号: 338154
• 负责人: Gao Xia
• 金额: $ 10.93万
• 依托单位: Duke University Medical Center (Durham, North Carolina)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2018-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=338154&lang=en
• 关键词: Cancer; Cancer Epigenetics; Computational Science; Histone Methylation; Mass Spectrometry; Methionine Metabolism; Next Generation Sequencing; One Carbon Metabolism

Cancer cells have distinct metabolic features that allow them to achieve uncontrolled proliferation, survival, and long-term maintenance. Cancer cells are known to have increased consumption of glucose for fermentation, namely the Warburg effect, but othe

癌细胞具有独特的代谢特征，使它们能够实现不受控制的增殖，存活和长期维持。已知癌细胞具有用于发酵的葡萄糖的增加的消耗，即瓦尔堡效应，但其他的细胞具有用于发酵的葡萄糖的增加的消耗。