Cancer Epigenetics Training Program

癌症表观遗传学培训计划

• 批准号: 10226244
• 负责人: Maria Eugenia Figueroa
• 金额: $ 27.47万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226244
• 关键词: Epigenetic Process; Malignant Neoplasms; Training Programs

Project Summary The aim of the proposal is to develop a dedicated Training Program in Epigenetics and Cancer with a translational component at the Sylvester Comprehensive Cancer Center (SCCC), University of Miami Miller School of Medicine. The objective of the training program is to offer postdoctoral fellows a sophisticated, scientific environment with multidisciplinary expertise encompassing epigenetics and cancer. The proposed program will provide trainees with the ideal platform for successful careers as scientists, physicians, scientific administrators, and entrepreneurs that will identify novel agents and devises to treat cancer. We have assembled a team of 18 SCCC members who will serve as mentors of this program, including 9 full Professors, 7 Associate Professors, and 2 Assistant Professors. All mentors are currently supported by R01 and/or R01 equivalent funding (e.g. Leukemia Lymphoma Society) for at least the next two years at the time of submission. The total funding of these mentors exceeds seven million dollars per year. Most of these mentors have trained outstanding postdoctoral fellows in the past ten years. In addition, these mentors are currently training 12 postdoctoral fellows that are eligible for these training grants. The research expertise of these mentors includes hematologic malignancies, carcinogenesis, epigenetics, cancer genomics, cancer biology, signal transduction, drug discovery, cancer control, and bioinformatics. The models used in their labs include primary cells and cell lines from tumors and animal models relevant to human cancers, such as hematopoietic malignancies, breast cancer, uveal melanoma, lung cancer, pancreatic cancer, prostate cancer, and brain cancer. A training program has been advanced for the postdoctoral fellows within the Cancer Epigenetics Program at SCCC, aiming to engage them in multidisciplinary interactions where they can get exposure to clinical cancer research and learn about unmet research needs that they can then bring to the bench. This training program includes biweekly cancer epigenetic colloquia for trainees, a weekly journal club, seminars from outside speakers, monthly epigenomics working group meetings, and internal workshops for grant writing and bioinformatics. These approaches will allow the trainees to keep up with the most up-to-date research activities and to apply advanced techniques/methods into their studies, thereby increasing their competitiveness. In addition, individual development plans will be implemented for each trainee to maximize their unique strengths and overcome their specific weaknesses. Our training program will maximize diversity and make every effort to recruit trainees from populations traditionally underrepresented in science and medicine. With our enthusiastic and dedicated mentors, carefully selected trainees, a multidisciplinary environment, and a strong commitment from our Institution, the proposed program will provide unique opportunities for our trainees to flourish in multi-dimensional thinking, problem solving and laboratory skills, as well as establish a workforce that will successfully produce the next generation researchers in Epigenetics and Cancer.

项目摘要 该提案的目的是制定一个专门的表观遗传学和癌症培训计划， 翻译组件在西尔维斯特综合癌症中心（SCCC），迈阿密大学米勒 医学院的。培训计划的目标是为博士后研究员提供一个复杂的，科学的 环境与多学科的专业知识，包括表观遗传学和癌症。拟议的方案将 为学员提供理想的平台，成功的职业生涯作为科学家，医生，科学管理人员， 和企业家，将确定新的代理人和设计，以治疗癌症。我们召集了一个18人的团队 SCCC成员谁将担任该计划的导师，包括9名正教授，7名副教授， 2助理教授所有导师目前都得到R 01和/或R 01同等资金的支持（例如 白血病淋巴瘤协会）至少在提交时的未来两年。这些资金总额 每年的指导费用超过七百万美元。这些导师大多培养出了优秀的博士后 在过去的十年里，此外，这些导师目前正在培训12名博士后研究员， 有资格获得这些培训赠款。这些导师的研究专长包括血液恶性肿瘤， 致癌作用，表观遗传学，癌症基因组学，癌症生物学，信号转导，药物发现，癌症 控制和生物信息学。他们实验室中使用的模型包括来自肿瘤的原代细胞和细胞系， 与人类癌症如造血系统恶性肿瘤、乳腺癌、葡萄膜黑色素瘤 肺癌、胰腺癌、前列腺癌和脑癌。一项培训方案已经提出， SCCC癌症表观遗传学项目的博士后研究员，旨在让他们参与 多学科的互动，他们可以接触到临床癌症研究，并了解未满足的 研究所需的信息，然后他们就可以把这些信息带到实验室。该培训计划包括每两周一次的癌症表观遗传学 学员座谈会，每周杂志俱乐部，外部演讲者研讨会，每月表观基因组学工作 小组会议和内部研讨会的授权写作和生物信息学。这些方法将允许 学员跟上最新的研究活动，并应用先进的技术/方法， 学习，从而提高竞争力。此外，个人发展计划将 为每个受训者实施了这一方案，以最大限度地发挥他们的独特优势，克服他们的具体弱点。我们 培训计划将最大限度地扩大多样性，并尽一切努力从传统上 在科学和医学领域代表性不足。与我们热情和敬业的导师，精心挑选 培训生，多学科的环境，以及我们机构的坚定承诺，拟议的计划 将为我们的学员提供独特的机会，在多维思维，解决问题， 实验室技能，以及建立一支能够成功培养下一代研究人员的队伍 表观遗传学和癌症