Combating Winter Ulcer Disease in Canadian Industry

加拿大工业对抗冬季溃疡病

• 批准号: 487386-2015
• 负责人: Muckle, Anne
• 金额: $ 1.82万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=586065
• 关键词: Combating; Winter; Ulcer; Disease; Canadian

Winter ulcer disease has mainly affected salmonids in Norway and Iceland, but also in Scotland, the Faroe Islands, Canada and Ireland. Outbreaks occur most commonly in Atlantic salmon, Salmo salar L., but also in rainbow trout, Oncorhynchus mykiss (Walbaum). The Gram-negative bacterium, Moritella viscosa is the main aetiological agent of winter ulcer disease at cold water temperatures (8-12°C) in seawater, however, Aliivibrio wodanis [formerly Vibrio wodanis] is often co-isolated with M. viscosa or as the only isolate from fish with the disease. Although winter ulcer disease was recognised more than 20 years ago, the pathogenesis of this disease is not yet fully understood and only a few virulence features have been characterized in Moritella viscosa. For knowledge-based development of vaccines and vaccine strategies, this is a considerable disadvantage. These outbreaks represent a serious threat to the industry, both directly in terms of the cost of aquatic health products and monitoring costs, and indirectly through impacts on production management decisions and, as with winter ulcer disease, in reduced carcass quality). This disease is the primary reason for antibiotic usage in aquaculture on the east coast of Canada and anecdotal reports suggest mortality from this disease is increasing although it is unclear as to why. The goals of the current work are to develop a challenge model for the study of M. viscose and characterize ulcer development so that future vaccine targets can be tested against this disease on a controlled setting. Furthermore, we will determine the impacts of common co-infection on pathology of winter ulcer disease.

冬季溃疡病主要影响挪威和冰岛的鲑鱼，但也影响到苏格兰的法罗群岛 岛屿、加拿大和爱尔兰。暴发最常见的是大西洋鲑鱼Salmo salar L.，但也有 虹鲑鱼Oncorhynchus mykis(Walbaum)。革兰氏阴性杆菌以粘性Moritella为主 海水中冷水温度(8-12℃)下冬季溃疡病的病原菌，然而，弧菌 Wodanis[前身为Wodanis弧菌]通常与粘性分枝杆菌共分离，或作为与 疾病。虽然冬季溃疡病早在20多年前就被认识到了，但这种疾病的发病机制 目前尚不完全清楚，粘性Moritella的毒力特征也只有少数几个。为 基于知识的疫苗开发和疫苗战略，这是一个相当大的劣势。这些 疫情对该行业构成了严重威胁，直接影响到水产保健品的成本。 和监测成本，并间接通过影响生产管理决策和冬季 溃疡病，降低了屠体质量)。该病是水产养殖中使用抗生素的主要原因。 在加拿大东海岸，坊间报道表明，这种疾病的死亡率正在上升，尽管它是 原因尚不清楚。当前工作的目标是为粘胶分枝杆菌的研究开发一个挑战模型。 并对溃疡的发展进行表征，以便未来的疫苗靶点可以在 受控设置。此外，我们还将确定常见的混合感染对冬季病理的影响。 溃疡病。