Investigation of Metal-Organic Hybrids as Photosensitizers for Bioinorganic Applications

金属有机杂化物作为生物无机应用光敏剂的研究

• 批准号: RGPIN-2015-04364
• 负责人: McFarland, Sherri
• 金额: $ 3.28万
• 依托单位: Acadia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589752
• 关键词: Investigation; Metal; Organic; Hybrids; Photosensitizers

My last NSERC DG period explored coordination complexes as DNA photocleaving agents, compounds that have utility as photosensitizers for photodynamic therapy (PDT). This strategy for treating cancer, whereby light activation of a photosensitizer produces cytotoxic singlet oxygen, is compromised by its reliance on oxygen, which is often limited in the most aggressive tumours.  My group used its multidisciplinary expertise to exploit novel photophysical principles in coordination chemistry to elicit oxygen-independent DNA photodamage by certain photosensitizer constructs. We were the first to show that highly reactive triplet intraligand (

我的最后一个NSERC DG期间探讨了作为DNA光裂解剂的配位络合物，这些化合物可用作光动力疗法（PDT）的光敏剂。这种治疗癌症的策略，即光敏剂的光活化产生细胞毒性单线态氧，由于其对氧的依赖而受到损害，而氧在最具侵袭性的肿瘤中往往受到限制。 我的小组利用其多学科的专业知识，利用配位化学中的新物理原理，通过某些光敏剂结构引起非氧依赖性DNA光损伤。我们是第一个显示高活性三联体配体内（