Function of ileal lipid binding proteins

脂肪酸结合蛋白（FABPs）是一种丰富的小分子量可溶性蛋白，存在于各种组织中。迄今为止，FABP家族有9个成员可以结合小的疏水化合物。每个FABP具有独特的配体特异性，并与某些组织相关。fabp具有相似的三维结构，尽管初级结构存在显著差异，这可能有助于其特征配体偏好。功能丧失突变为了解FABP在各种代谢过程中的功能提供了重要的见解，但FABP的精确分子功能仍未得到很好的理解。这些蛋白可以作为细胞的储存库、各自配体的细胞内转运体，并作为细胞内转运体（内化配体的膜结合转运体）和与基因启动子结合的同源核受体之间的穿梭体。

Fatty acid binding proteins (FABPs) are abundant, small molecular weight soluble proteins found in various tissues. To date, the FABP family has 9 members that bind small hydrophobic compounds. Each FABP has a distinct ligand specificity and is associated with certain tissues. FABPs have similar three dimensional structures despite significant dissimilarity in primary structures which likely contributes to their characteristic ligand preferences. Loss-of-function mutations gave important insights into FABP function in a variety of metabolic processes, but the precise molecular functions of FABPs are still not well understood. These proteins may act as cellular storage depots, intracellular transporters for their respective ligands, and serve as intracellular shuttles between the membrane-bound transporter that internalize their ligands and the cognate nuclear receptors bound to gene promoters.