Function of ileal lipid binding proteins

回肠脂质结合蛋白的功能

• 批准号: RGPIN-2015-04390
• 负责人: Agellon, Luis
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630057
• 关键词: Function; ileal; lipid; binding; proteins

Fatty acid binding proteins (FABPs) are abundant, small molecular weight soluble proteins found in various tissues. To date, the FABP family has 9 members that bind small hydrophobic compounds. Each FABP has a distinct ligand specificity and is associated with certain tissues. FABPs have similar three dimensional structures despite significant dissimilarity in primary structures which likely contributes to their characteristic ligand preferences. Loss-of-function mutations gave important insights into FABP function in a variety of metabolic processes, but the precise molecular functions of FABPs are still not well understood. These proteins may act as cellular storage depots, intracellular transporters for their respective ligands, and serve as intracellular shuttles between the membrane-bound transporter that internalize their ligands and the cognate nuclear receptors bound to gene promoters.

脂肪酸结合蛋白（Fatty Acid Binding Proteins，FABPs）是一种存在于多种组织中的小分子量可溶性蛋白质。迄今为止，FABP家族有9个成员结合小的疏水化合物。每个FABP具有不同的配体特异性，并与某些组织相关。FABPs具有相似的三维结构，尽管一级结构显著不同，这可能有助于其特征性配体偏好。功能丧失突变对FABP在各种代谢过程中的功能提供了重要的见解，但FABP的精确分子功能仍然没有得到很好的理解。这些蛋白质可以作为细胞储存库，其各自配体的细胞内转运蛋白，并作为内化其配体的膜结合转运蛋白和与基因启动子结合的同源核受体之间的细胞内穿梭。