Lariat Peptide Inhibitors of the Transcription Factor ETV6

转录因子 ETV6 的套索肽抑制剂

• 批准号: 350054
• 负责人: Scheu Karlton
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=350054&lang=en
• 关键词: Cyclic Peptides; Dna Binding Inhibition; Dna-Protein Interface; Ets; Nmr; Protein-Protein Interractions; Transcription Factors

Specifically inhibiting protein-DNA interactions with small molecules is a holy grail of drug development. A promising solution to this difficult task is to use peptides as inhibitors, which have protein-like features and are able to strongly bind protein

特异性抑制蛋白质-DNA与小分子的相互作用是药物开发的圣杯。解决这一难题的一个有希望的方法是使用肽作为抑制剂，肽具有蛋白质样特征，能够强烈地结合蛋白质