Investigating a biological specificity conundrum: the role of dynamics in transcription factor binding

研究生物特异性难题：动力学在转录因子结合中的作用

• 批准号: 406750
• 负责人: Scheu Karlton
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=406750&lang=en
• 关键词: Dna Binding; Electrophoretic Mobility Shift Assay; Next-Gen Sequencing; Nuclear Magnetic Resonance Spectroscopy; Protein Dynamics; Transcription Factors

Transcription factors (TF) are proteins that bind specific regions of our DNA and thereby turn genes on/off. Many diseases, including cancers, are caused by misregulation of gene expression, so fully understanding how a TF functions is key to understandin

转录因子（TF）是结合我们DNA特定区域的蛋白质，从而打开/关闭基因。包括癌症在内的许多疾病都是由基因表达的失调引起的，因此充分了解TF的功能是理解TF的关键。