Molecules and mechanisms that regulate asymmetric cell division

调节不对称细胞分裂的分子和机制

• 批准号: RGPIN-2015-04669
• 负责人: Maxwell, Christopher
• 金额: $ 2.19万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589940
• 关键词: Molecules; mechanisms; regulate; asymmetric; cell

Cell division produces two daughter cells that are genetically identical to the mother cell. However, the cell division of a neural stem cell can produce two genetically identical daughter cells that have dissimilar long-term functions. Such asymmetric cell division of a mother stem cell generates 1 daughter cell that functions as a stem cell, which maintains the stem cell pool, and 1 daughter cell that can differentiate and support homeostasis in the tissue.

细胞分裂产生两个子细胞，它们在遗传上与母细胞相同。然而，神经干细胞的细胞分裂可以产生两个基因相同但具有不同长期功能的子细胞。母干细胞的这种不对称细胞分裂产生1个作为干细胞发挥功能的子细胞，其维持干细胞库，以及1个可以分化并支持组织中的稳态的子细胞。