Antigen-presenting and phagocytic functions of B cell subsets

B 细胞亚群的抗原呈递和吞噬功能

• 批准号: RGPIN-2015-04714
• 负责人: Stager, Simona
• 金额: $ 2.19万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589967
• 关键词: Antigen; presenting; phagocytic; functions; cell

B-cells are mostly known for their capacity to produce antibodies. However, an increasing body of literature has now shown that they may also participate in the immune response by various antibody-independent mechanisms, such as cytokine production, co-stimulation, and antigen presentation. B-cells can be divided in three different subpopulations: follicular B cells or B2 cells, innate-like marginal zone B-cells (MZB), and B1 B-cells. Follicular B cells are the most prominent B-cell subpopulation and reside in lymphoid follicles of secondary and tertiary lymphoid organs. MZB are located in the marginal zone of the spleen and are endowed with the capacity to bind immune complexes, migrate towards the splenic white pulp, and transfer antigen to follicular dendritic cells. B1 B-cells are known for their secretion of natural antibodies.

b细胞以其产生抗体的能力而闻名。然而，越来越多的文献表明，它们也可能通过各种抗体独立机制参与免疫应答，如细胞因子产生、共刺激和抗原呈递。B细胞可分为三个不同的亚群：滤泡B细胞或B2细胞，先天样边缘带B细胞（MZB）和B1 B细胞。滤泡B细胞是最重要的B细胞亚群，存在于二级和三级淋巴器官的淋巴滤泡中。MZB位于脾脏边缘区，具有结合免疫复合物、向脾白髓迁移、将抗原转移到滤泡树突状细胞的能力。B1 b细胞以分泌天然抗体而闻名。