Evaluation of a novel model of skeletal muscle fatigue

骨骼肌疲劳新模型的评估

• 批准号: RGPIN-2015-05113
• 负责人: MacIntosh, Brian
• 金额: $ 2.04万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590231
• 关键词: Evaluation; novel; model; skeletal; muscle

Skeletal muscle fatigue, is a common experience that has fascinated scientists for centuries, yet the cellular processes impacting contractile properties during and following repeated activations are not understood. Most theories of fatigue considered build-up of products of metabolism and inhibition of the contractile response. This is not consistent with the known primary mechanism of fatigue: inhibition of excitation-contraction coupling (E-CC). It is time to study how E-CC is impaired. An innovative explanation for muscle fatigue is proposed: fatigue is a consequence of cellular regulation of E-CC to preserve energy charge in the muscle. Experiments are proposed to test this theory as well as alternative theories. Experiments are proposed using: single fibre, fibre bundles and whole muscle at physiological temperature. It has been demonstrated that fatigue mechanisms at room temperature are not relevant at physiological temperature. A second innovative and practical aspect of the proposed studies is contractions under consideration will be sub maximal, like natural contractions in common movements.

骨骼肌疲劳是一种常见的经历，几个世纪以来一直吸引着科学家，但在反复激活期间和之后影响收缩特性的细胞过程尚不清楚。大多数疲劳理论认为是代谢产物的积累和收缩反应的抑制。这与已知的疲劳的主要机制不一致：抑制兴奋-收缩偶联（E-CC）。现在是研究E-CC受损的时候了。对肌肉疲劳提出了一种新的解释：疲劳是细胞调节E-CC以保存肌肉中的能量电荷的结果。提出实验来测试这个理论以及替代理论。实验建议使用：单纤维，纤维束和整个肌肉在生理温度。已经证明，室温下的疲劳机制与生理温度无关。所提出的研究的第二个创新和实用方面是所考虑的收缩将是次最大的，就像常见运动中的自然收缩一样。