Molecular Engineering of Deoxyribozymes for Amplified Protein Detection and Cell Imaging

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Proteins are essential components of all living organisms, performing a vast array of functions ranging from expressing the genomic information to maintaining homeostasis. They are also a class of important biomarkers for disease diagnostics. Current protein detection techniques (e.g., ELISA, Western blot, immuno-PCR) typically require complicated instrumentation, tedious operations, and well-trained personnel with specialized techniques, and thus are not amenable for many practical uses, such as point-of-care disease diagnostics and high throughput analysis. Our research program will focus on addressing current challenges in protein analysis by developing new chemical and biological tools with applications ranging from fundamental research to personalized healthcare.