Catalysis by Phospino Gold Complexes: Application in Synthesis and Photoredox Transformations

膦金配合物的催化：在合成和光氧化还原转化中的应用

基本信息

批准号：
RGPIN-2015-05384
负责人：
Barriault, Louis
金额：
$ 5.39万
依托单位：
University of Ottawa
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590396
关键词：
Catalysis Phospino Gold Complexes Application

项目摘要

The development of new synthetic methods for the formation of carbon-carbon bond is of paramount importance for the efficient synthesis of molecules having important application in medicine and material science. Most of the traditional chemical reactions to construct carbon-carbon bonds have a poor atom economy i.e. the amount of reagents does not equal the amount of all products produced thus leading to a waste of atoms. The ever-increasing emphasis being placed on sustainability and environmental problems, the need for efficient and waste-minimizing processes is becoming more and more important. Homogenous catalysis by transition metals has emerged as one of the most important field in organic chemistry. In the recent years, homogenous catalysis by coinage metals has received considerable attention by the scientific community. For instance, the high affinity of Au(I/III) salts for alkynes and allenes in the presence of many other functional groups, combined with its ability to stabilize cationic charge provide tremendous opportunities for the discovery novel and useful reactions. In addition, phosphino dimeric gold complexes can be used as photocatalyst owing to their high-energy and long-lived excited states and stronger reduction potentials. Thus, these photoexcited catalysts can be used to generate free radicals from unactivated carbon-halogen bonds. The goal of this research program is to develop new coinage metal-catalyzed cyclization and photoredox transformations of general applicability for the synthesis of complex natural products.

形成新的合成方法的发展对于有效合成在医学和材料科学中具有重要应用的分子至关重要。构建碳碳键的大多数传统化学反应的原子经济差，即试剂的量并不等于所有产生的产品的量，从而导致原子浪费。不断增加的重点放在可持续性和环境问题上，对高效和浪费最小过程的需求变得越来越重要。过渡金属均匀催化已成为有机化学中最重要的领域之一。近年来，造币金属的同质催化受到了科学界的极大关注。例如，在许多其他功能组的存在下，Au（I/III）盐对炔烃和艾伦斯的高亲和力，结合其稳定阳离子电荷的能力为发现小说和有用的反应提供了巨大的机会。另外，由于其高能量和长寿的激发态和更强的还原电位，磷酸二聚体金复合物可以用作光催化剂。因此，这些光激发的催化剂可用于从未活化的碳纤维键产生自由基。该研究计划的目的是开发新的造币金属催化的环化和对复杂天然产物合成的一般适用性的光电毒转换。