Dynamic biomaterials to study, manipulate and screen cell-matrix interactions

用于研究、操纵和筛选细胞-基质相互作用的动态生物材料

• 批准号: RGPIN-2015-05429
• 负责人: Wylie, Ryan
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590423
• 关键词: Dynamic; biomaterials; study; manipulate; screen

Biomaterials based strategies have the potential to improve human health by understanding and controlling the way cells behave with their environment, which will ultimately lead to the development of materials for the treatment of diseases. Cells are surround by a dynamic four-dimensional extracellular matrix (ECM) composed of chemical and mechanical signals in the form of macromolecules that change in space and time. Currently, we rely on outdated and inefficient tools to study the cell-material interfaces that exists in the ECM. Therefore, we need to build materials where properties can be easily tailored and changed over time to probe interactions at the cell-material interface. There is a great opportunity for material scientists and biologists to work together to better understand the importance of the cellular environment and better elucidate how, when and why materials influence cellular behaviours.

基于生物材料的策略有可能通过理解和控制细胞与其环境的行为方式来改善人类健康，这将最终导致用于治疗疾病的材料的开发。细胞被动态的四维细胞外基质（ECM）包围，ECM由化学和机械信号组成，以大分子的形式在空间和时间上变化。目前，我们依赖于过时和低效的工具来研究ECM中存在的细胞-材料界面。因此，我们需要构建的材料的性质可以很容易地定制和随着时间的推移而改变，以探测细胞-材料界面的相互作用。材料科学家和生物学家有很好的机会共同努力，更好地了解细胞环境的重要性，并更好地阐明材料如何，何时以及为什么影响细胞行为。