Effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) on lipoprotein receptor-mediated bacterial lipid clearance and hepatic inflammation in sepsis

前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 对脂蛋白受体介导的细菌脂质清除和脓毒症肝脏炎症的影响

• 批准号: 349908
• 负责人: Grin Peter M
• 金额: $ 1.27万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=349908&lang=en
• 关键词: Cecal Ligation And Puncture (Clp); Hepatic Inflammation; Intravital Microscopy; Leukocyte Recruitment; Lipopolysaccharide (Lps); Lipoteichoic Acid (Lta); Low Density Lipoprotein Receptor (Ldlr); Low Density Lipoprotein Receptor-Related Protein 1 (Lrp-1)

Sepsis is a devastating disease that affects millions of people each year, and is fatal in about 30-50% of affected patients. Sepsis results when the immune system overreacts to an infection, resulting in inflammation throughout the entire body (also know

败血症是一种毁灭性的疾病，每年影响数百万人，大约30%-50%的受影响患者是致命的。当免疫系统对感染反应过度，导致全身发炎时，败血症就会发生(也称为